Evidence map›Paper›PMID 40415579›Full record

ArticleThe European journal of neuroscience2025

Left Ventral Caudate Functional Connectivity Mediates the Relationship Between Habitual Responding and Alcohol Use.

Lindsey R Fisher-Fox, Mario Dzemidzic, McKenzie R Cox, David Haines, James Hays, Mayande K Mlungwana, Zachary Whitt, Andrea Avena-Koenigsberger, Ann E K Kosobud, David A Kareken and 3 more

Abstract read
In one paragraph

Article in The European journal of neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Sex-Based Mechanisms of Stress-Induced Alcohol-Seeking.Behavioral sciences (Basel, Switzerland) · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lindsey R Fisher-FoxDepartment of Psychology, Indiana University Indianapolis, Indianapolis, USA.
Mario DzemidzicDepartment of Neurology, Indiana University School of Medicine, Indianapolis, USA.
McKenzie R CoxDepartment of Psychiatry, Indiana University School of Medicine, Indianapolis, USA.
David HainesDepartment of Psychiatry, Indiana University School of Medicine, Indianapolis, USA.
James HaysDepartment of Psychiatry, Indiana University School of Medicine, Indianapolis, USA.
Mayande K MlungwanaDepartment of Psychiatry, Indiana University School of Medicine, Indianapolis, USA.
Zachary WhittDepartment of Psychology, Indiana University Indianapolis, Indianapolis, USA.
Andrea Avena-KoenigsbergerDepartment of Neurology, Indiana University School of Medicine, Indianapolis, USA.
Ann E K KosobudDepartment of Psychiatry, Indiana University School of Medicine, Indianapolis, USA.
David A KarekenDepartment of Neurology, Indiana University School of Medicine, Indianapolis, USA.
Sean O'ConnorDepartment of Psychiatry, Indiana University School of Medicine, Indianapolis, USA.
Martin H PlaweckiDepartment of Psychiatry, Indiana University School of Medicine, Indianapolis, USA.
Melissa A CydersDepartment of Psychology, Indiana University Indianapolis, Indianapolis, USA.ORCID 0000-0003-1990-8337

Funding

Translational Research and Science Education (OUT)P60AA007611 · NIAAA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI DAVID A. KAREKEN · 2003 to 2026
$45.5M
Indiana Clinical and Translational Sciences InstituteUM1TR004402 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI Sharon M Moe, Sarah Elizabeth Wiehe · 2023 to 2026
$21.6M
NCATS NIH HHS UM1 TR004402NIAAA NIH HHS P60 AA007611NIAAA NIH HHS P60AA007611
6 · The paper itself

Abstract

Preclinical studies posit that habitual behaviour is an important mechanism in the development of alcohol use disorder (AUD), but human findings are unclear. The goals of this study were to test a behavioural measure of habit formation, the Slips of Action Task (SOAT), in humans and identify brain-based mechanisms explaining the relationship between habit and alcohol use. Thirty-six participants (63.9% female, mean age = 30.58, SD = 9.73, 69.4% White, 83.3% Not Hispanic/Latino) who endorsed heavy drinking completed self-report measures, the SOAT (lower scores = higher habit formation), a 2.5-h intravenous alcohol self-administration session, and a resting-state functional magnetic resonance imaging scan. Three seed regions-bilateral ventral caudate, nucleus accumbens and dorsal caudate-were assessed for significant whole brain functional connectivity (FC) associations with SOAT (cluster-level p

Indexed as

Alcohol DrinkingCaudate NucleusHabitsAdultAlcoholismFemaleHumansMagnetic Resonance ImagingMaleNeural PathwaysNucleus AccumbensYoung Adultfunctional magnetic resonance imaginghabitual behaviourhumanintravenous alcohol self‐administrationresting state

Identifiers

PMID40415579
PMCPMC12104795

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.