ArticleACS omega2025
Carboxychalcones Based on Terephthalaldehydic Acid as Potential Neuroprotective Agents. Synthesis, Computational Study and Biological Evaluation.
Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Microwave-Assisted Synthesis of Imidazole-Based Chalcones: Modulating Antimicrobial Activity Through Alkoxy Substitutions.Antibiotics (Basel, Switzerland) · 2026Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This work aimed to synthesize a series of carboxychalcones and determine their efficacy as neuroprotective agents in vitro. All carboxychalcones were synthesized from terephthalaldehydic acid, an aromatic aldehyde with a carboxy group, using the Claisen-Schmidt condensation method and evaluated through in silico analyses and various biological tests. The potential of chalcones derivatives bearing carboxy groups in the ring as neuroprotective agents was tested by assessing their biological effects in the in vitro model of neural cells (HT-22) inter alia, using the resazurin reduction assay, the LDH release test and flow cytometry-based methods, followed by determining the specific protein expression by Western Blot. Our research suggests that compounds
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Registered trials
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