Evidence map›Paper›PMID 40415978›Full record

ArticleHealth science reports2025

The Association Between Serum Uric Acid Levels and the 10-Year Prospective Risk of Dyslipidemia: A Cohort Study From Healthy Heart Project (YHHP).

Hamidreza Mohammadi, Seyed Reza Mirjalili, Pedro Manuel Marques-Vidal, Marzieh Azimizadeh, Seyede Mahdiah Nemayandah, Mohammadtaghi Sarebanhassanabadi, Sedighe Sadeghi

Abstract read
In one paragraph

Article in Health science reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hamidreza MohammadiYazd Cardiovascular Research Center, Non-communicable Diseases Research Institute Shahid Sadoughi University of Medical Sciences Yazd Iran.ORCID https://orcid.org/0000-0002-7104-5295
Seyed Reza MirjaliliYazd Cardiovascular Research Center, Non-communicable Diseases Research Institute Shahid Sadoughi University of Medical Sciences Yazd Iran.ORCID https://orcid.org/0000-0001-8568-201X
Pedro Manuel Marques-VidalDepartment of Medicine, Internal Medicine Lausanne University Hospital and University of Lausanne Lausanne Switzerland.ORCID https://orcid.org/0000-0002-4548-8500
Marzieh AzimizadehYazd Cardiovascular Research Center, Non-communicable Diseases Research Institute Shahid Sadoughi University of Medical Sciences Yazd Iran.ORCID https://orcid.org/0000-0001-8618-1778
Seyede Mahdiah NemayandahDepartment of Epidemiology Shahid Sadoughi University of Medical Sciences Yazd Iran.ORCID https://orcid.org/0000-0003-3616-2864
Mohammadtaghi SarebanhassanabadiYazd Cardiovascular Research Center, Non-communicable Diseases Research Institute Shahid Sadoughi University of Medical Sciences Yazd Iran.ORCID https://orcid.org/0000-0002-8867-4717
Sedighe SadeghiYazd Cardiovascular Research Center, Non-communicable Diseases Research Institute Shahid Sadoughi University of Medical Sciences Yazd Iran.ORCID https://orcid.org/0009-0001-7778-9308

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Aims: Dyslipidemia is a major risk factor for cardiovascular disease (CVD) and is increasingly prevalent globally, particularly in developing countries undergoing lifestyle transitions. Serum uric acid (SUA) has been implicated in various metabolic disorders, including dyslipidemia. This study aimed to evaluate the association between high SUA and the 10-year prospective risk of dyslipidemia. Methods: This cohort study uses data from the Yazd Healthy Heart Project (YHHP). Participants were followed for 10 years, during which the association between dyslipidemia incidence and SUA levels was assessed using multivariate Cox proportional hazard models. Results: Among 693 participants analyzed, higher SUA quartiles were associated with older age, male gender, and adverse anthropometric and metabolic profiles. Elevated SUA levels correlated positively with triglycerides ( Conclusion: Elevated SUA levels independently associated with the development of dyslipidemia over a decade in an Iranian population. The findings underscore the potential utility of SUA as a biomarker for assessing dyslipidemia risk, particularly in men. Further research should explore mechanistic pathways linking SUA to dyslipidemia and evaluate interventions targeting SUA reduction to mitigate dyslipidemia risk.

Indexed as

cohort studydyslipidemiaserum uric acid

Identifiers

PMID40415978
PMCPMC12098965

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.