ArticleCureus2025
Spontaneous Resolution of a Full-Thickness Macular Hole: A Complex History.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
0 citing papers in PubMed.
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Macular holes are vision-threatening retinal conditions that can significantly affect a patient's quality of life. Secondary macular holes, often associated with intricate ocular histories, create significant obstacles in effective patient management. This case report discusses a gentleman in his 60s, whose routine monitoring for proliferative diabetic retinopathy revealed the emergence of a small full-thickness macular hole, likely worsened by his complex ocular history. His ocular history included a pars plana vitrectomy combined with heavy silicone oil tamponade following a traumatic retinal detachment three years earlier, alongside pan-retinal photocoagulation, anti-vascular endothelial growth factor and steroid injections for his diabetic eye disease. Spontaneous closure of the full-thickness macular hole within three months not only improved visual acuity from 1.04 LogMAR to 0.68 LogMAR but also illustrates the retina's natural reparative capabilities. This underscores the complex aetiology of secondary full-thickness macular holes, highlighting the interplay of trauma, proliferative diabetic retinopathy, anti-vascular endothelial growth factor treatments, and prior surgeries. Observation, especially in smaller secondary holes, can be a practical approach, using the retina's natural reparative processes while avoiding surgical risks.
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Registered trials
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