ArticleFrontiers in nutrition2025
A cross-sectional analysis of dietary selenium intake and type 2 diabetes risk in adults: insights from NHANES 2011-2016.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Association of triglyceride-glucose index with carotid atherosclerosis in the general population: a case-control study of 14,535 participants.BMC cardiovascular disorders · 2026Article
- Moderating effect of selenium intake on the association between obesity and sex hormone levels in children and adolescents: NHANES 2013-2016.Asia Pacific journal of clinical nutrition · 2026Article
- A U-shaped association between blood selenium levels and prostate cancer: findings of a case-control study among Nigerian men.Scientific reports · 2025Article
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Authors and funding
7 authors.
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Abstract
Objective: While selenium exhibits antioxidant properties, its association with type 2 diabetes mellitus (T2DM) remains controversial. This study aimed to investigate the relationship between dietary selenium intake and T2DM risk in a nationally representative population. Methods: We conducted a cross-sectional analysis of 2,170 adults from the National Health and Nutrition Examination Survey (NHANES) 2011-2016. Using weighted multivariable logistic regression, we estimated adjusted ORs with 95% CIs across selenium intake quartiles. Restricted cubic splines with three knots (10th, 50th, and 90th percentiles) were employed to characterize non-linear associations. Additionally, stratified analyses were performed based on age, sex, ethnicity, BMI, smoking status, and drinking status. Results: A significant U-shaped relationship was observed between dietary selenium intake and T2DM risk ( Conclusion: Both insufficient and excessive dietary selenium intake may elevate the risk of T2DM, with an optimal range identified through non-linear modeling. Targeted selenium recommendations for obese individuals could mitigate diabetes risk, though longitudinal studies are needed to confirm causality. These findings highlight the importance of personalized nutrition strategies in high-risk populations.
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