ArticleInternational journal of nephrology and renovascular disease2025
Growth Differentiation Factor-15 as a Potential Biomarker for Renal Involvement in POEMS Syndrome.
Article in International journal of nephrology and renovascular disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome is a rare plasma cell dyscrasia. Growth differentiation factor-15 (GDF-15) is related with renal function, but few studies have focused on it in renal impairment of POEMS syndrome. Objective: To evaluate the potential of circulating GDF-15 concentration as a biomarker for renal function in POEMS syndrome. Methods: 150 Chinese patients, diagnosed with POMES syndrome, were enrolled and divided into three subgroups according to their chemotherapy stage. All the patients' medical records were retrospectively analyzed and plasma VEGF and GDF-15 were measured using ELISA kits. Treatment-naïve patients were followed up for 13±6 months. Results: Plasma GDF-15 concentration positively correlated with serum creatinine (r=0.4048; Conclusion: Circulating GDF-15 concentration is associated with serous effusion, renal function and risk stratification, while a plasma GDF-15 < 547.8 pg /mL can help rule out renal impairment in POEMS syndrome. Baseline plasma GDF-15 is associated with renal remission after chemotherapy.
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