Evidence map›Paper›PMID 40416526›Full record

ArticleFrontiers in endocrinology2025

Fatty acid metabolism after short-term fasting: POMC response and EPA signal maintain homeostasis in tilapia.

Xiaozheng Yu, Tiansheng Zhu, Yang Yu, Ran Cai, Meiqing Li, Caiyun Sun, Wensheng Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xiaozheng Yu *State Key Laboratory of Biocontrol, Institute of Aquatic Economic Animals and Guangdong Province Provincial Engineering Technology Research Center for Healthy Breeding of Important Economic Fish, School of Life Sciences, Sun Yat-Sen University, Guangzhou, China.
Tiansheng Zhu *State Key Laboratory of Biocontrol, Institute of Aquatic Economic Animals and Guangdong Province Provincial Engineering Technology Research Center for Healthy Breeding of Important Economic Fish, School of Life Sciences, Sun Yat-Sen University, Guangzhou, China.
Yang YuState Key Laboratory of Biocontrol, Institute of Aquatic Economic Animals and Guangdong Province Provincial Engineering Technology Research Center for Healthy Breeding of Important Economic Fish, School of Life Sciences, Sun Yat-Sen University, Guangzhou, China.
Ran CaiState Key Laboratory of Biocontrol, Institute of Aquatic Economic Animals and Guangdong Province Provincial Engineering Technology Research Center for Healthy Breeding of Important Economic Fish, School of Life Sciences, Sun Yat-Sen University, Guangzhou, China.
Meiqing LiState Key Laboratory of Biocontrol, Institute of Aquatic Economic Animals and Guangdong Province Provincial Engineering Technology Research Center for Healthy Breeding of Important Economic Fish, School of Life Sciences, Sun Yat-Sen University, Guangzhou, China.
Caiyun SunState Key Laboratory of Biocontrol, Institute of Aquatic Economic Animals and Guangdong Province Provincial Engineering Technology Research Center for Healthy Breeding of Important Economic Fish, School of Life Sciences, Sun Yat-Sen University, Guangzhou, China.
Wensheng LiState Key Laboratory of Biocontrol, Institute of Aquatic Economic Animals and Guangdong Province Provincial Engineering Technology Research Center for Healthy Breeding of Important Economic Fish, School of Life Sciences, Sun Yat-Sen University, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Detecting and responding to fluctuations in fatty acid levels is crucial for maintaining the homeostasis of fatty acid metabolism. This study examined changes in neuropeptide levels and fatty acid sensing systems in tilapia following 24-hour fasting. Subsequently, an EPA compensation experiment was conducted to examine the regulatory effects of hypothalamic neuropeptides on feeding activity, fatty acid sensing systems activation, and alterations in AMPK and AKT signaling pathways in tilapia. After fasting, the neuropeptide Y signals in the preglomerular nucleus region increased significantly, while the POMC in the lateral tuberal nucleus significantly decreased. There was a significant increase in most long-chain fatty acids, excluding the EPA which declined. Fasting activates fatty acid sensing systems regulated by fatty acid metabolism and mitochondrial activity in the hypothalamus, and those regulated by CD36, mitochondrial activity and PKC in the liver. However, it inhibited systems regulated by fatty acid metabolism and lipoprotein lipase in the liver. Intraperitoneal EPA injection raised

Indexed as

Eicosapentaenoic AcidFastingFatty AcidsHomeostasisPro-OpiomelanocortinTilapiaAnimalsHypothalamusLiverSignal TransductionEicosapentaenoic AcidFatty AcidsPro-OpiomelanocortinEPAfatty acid sensing systemPOMCshort-term fastingtilapia

Identifiers

PMID40416526
PMCPMC12098032

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.