ArticleFrontiers in aging neuroscience2025
Obesity paradox in cognitive function: a longitudinal study of BMI and cognitive impairment in older adult Chinese population.
Article in Frontiers in aging neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Independent and Combined Effects of Obesity and Cardiovascular Diseases on the Risk of Cognitive Impairment and Dementia: A Systematic Review and Meta-Analysis of Prospective Cohort Studies Involving 8,276,914 Participants.International journal of molecular sciences · 2026Pooled it
- Vitamin D supplement intake is associated with better cognition in persons with sleep disturbance and mild cognitive impairment.Sleep medicine · 2026Article
- The role of vascular risk factors in white matter tract microstructure: a multi-cohort study in older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- High- and low-frequency accelerated repetitive transcranial magnetic stimulation for major depressive disorder.European archives of psychiatry and clinical neuroscience · 2026Article
- Association between the cardiometabolic index and intrinsic capacity and its domains in older adults: a study based on CHARLS data.BMC geriatrics · 2026Article
- Leveraging interpretable machine learning to identify sarcopenia in middle-aged and older adults with intrinsic capacity decline: an analysis of CHARLS data under AWGS 2025.BMC medical informatics and decision making · 2026Article
- Article
- Association between waist-to-height ratio and cognitive impairment among community-dwelling elderly adults in Laoshan, Qingdao: a cross-sectional study.Frontiers in nutrition · 2026Article
- The U-shaped Association between Body Mass Index (BMI) and Cognitive Impairment: Associated Characteristics in Low BMI and High BMI Chinese Adults.Diabetes & metabolism journal · 2026Article
- Serum Albumin/Globulin Ratio and Cognitive Function in Americans: A Linear Association.Brain and behavior · 2025Article
- Explainable machine learning-driven models for predicting Parkinson's disease and its prognosis: obesity patterns associations and models development using NHANES 1999-2018 data.Lipids in health and disease · 2025Article
- Impact of visceral adiposity index on cognitive impairment and cognitive trajectories in Chinese middle-aged and older adults.Frontiers in public health · 2025Article
- U-shaped association between BMI and cognitive impairment in middle-aged and older adults with type 2 diabetes: effect modification by lifestyle and exercise.Frontiers in public health · 2025Observational
Corrections and comments
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11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This study endeavored to investigate the correlation between body mass index (BMI) and cognitive impairment in the demographic of Chinese individuals who are 60 years of age and above. Methods: We selected data from China Health and Retirement Longitudinal Study (CHARLS) 2015-2018 and 2,942 subjects aged ≥60 years were included. The Mini-Mental State Examination (MMSE) was used to assess cognitive impairment. BMI was examined in two forms: as a continuous variable and was stratified into tertiles. Analysis was conducted using both univariate and multivariate logistic regression. Non-linear relationships were analyzed using curve fitting and segmented logistic regression. Results: During the study, 600 out of 2,942 subjects (20.4%) experienced cognitive impairment. In fully adjusted models, each unit increase in BMI was related to a 4% decrease in the odds of cognitive impairment (OR: 0.96, 95% CI: 0.93-0.99, Conclusion: This study provides evidence supporting the "obesity paradox" in the cognitive function of older adult Chinese population. Higher BMI is linked to lower cognitive impairment risk, especially among overweight persons. These findings indicate a complex and non-linear link between BMI and cognitive health among older adult adults, emphasizing the importance of tailored strategies for weight management in this population.
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