Evidence map›Paper›PMID 40417308›Full record

ArticleNature and science of sleep2025

Elevated Serum Level of Krebs von den Lungen-6 Predicts Death in Patients With Comorbid Idiopathic Pulmonary Fibrosis and Obstructive Sleep Apnea.

Fei Li, Jing Geng, Hehe Zhang, Bingbing Xie, Hui Zhang, Jiang Xie, Huaping Dai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature and science of sleep, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Fei LiDepartment of Pulmonary and Critical Care Medicine, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, People's Republic of China.
Jing GengNational Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Capital Medical University, Beijing, 100029, People's Republic of China.
Hehe ZhangDepartment of Pulmonary and Critical Care Medicine, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, People's Republic of China.
Bingbing XieNational Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Capital Medical University, Beijing, 100029, People's Republic of China.
Hui ZhangNational Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Capital Medical University, Beijing, 100029, People's Republic of China.
Jiang XieDepartment of Pulmonary and Critical Care Medicine, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, People's Republic of China.ORCID 0000-0002-1737-9083
Huaping DaiNational Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Capital Medical University, Beijing, 100029, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Obstructive sleep apnea (OSA) is prevalent in patients with idiopathic pulmonary fibrosis (IPF). This study evaluated the prognostic significance of Krebs von den Lungen-6 (KL-6) levels in patients with comorbid OSA and IPF. Methods: This retrospective research included 115 individuals diagnosed with IPF between January 2015 and December 2020, all of whom completed sleep tests and underwent measurement of serum KL-6 levels during hospitalization. To ascertain the risk factors associated with all-cause death, a multivariate Cox regression model was employed, adjusted for confounding variables of age, sex, and pulmonary function. Results: During the 40-month follow-up, 24 (20.9%) deaths occurred, with 17 (28.8%) in the OSA group and 7 (12.5%) in the non-OSA group. Patients with OSA had higher baseline KL-6 levels than did those without OSA. Both apnea-hypopnea index (hazard ratio [HR] = 1.023, 95% confidence interval [CI] 1.000-1.047, Conclusion: KL-6 level is of prognostic value in patients with comorbid IPF and OSA. These findings underscore the need for sleep tests and KL-6 measurement for IPF patients at high risk.

Indexed as

deathidiopathic pulmonary fibrosisobstructive sleep apneaserum Krebs von den Lungen-6

Identifiers

PMID40417308
PMCPMC12101450

What Socratic holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.