ArticleFrontiers in veterinary science2025
Rutin and
Article in Frontiers in veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Ameliorative effects ofFrontiers in veterinary science · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Monosodium glutamate (MG) is a substance often used to enhance food flavor, but its effect on the reproductive system is known to have a negative impact. This study assessed the protective effects of rutin (RUT) and Methods: There were six groups: Control, RUT, MOLE, MG, RUT + MG, and MOLE + MG. The critical parameters measured were testicular index, hormone levels, antioxidants, oxidative stress markers, inflammation, apoptosis and histopathological changes. Results: Following MG exposure (60 mg/kg/day for 30 days), the testicular index and serum testosterone, LH, and FSH levels were significantly reduced. The markers of oxidative stress increased, whereas the antioxidants decreased. The levels of inflammatory and apoptotic markers increased. The increased expression of inflammatory and apoptotic markers and significant testicular tissue damage, including degenerative changes in the seminiferous tubules, infiltration of inflammatory cells, and deposition of collagen fibers were investigated in addition to an increase in inflammatory and apoptotic markers. Discussion: The present study showed that pre-administration of RUT or MOLE ameliorated the deleterious effects of MG, possibly due to antioxidant and anti-inflammatory properties, indicating a protective effect of RUT and MOLE on MG-induced testicular toxicity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.