Evidence map›Paper›PMID 40417579›Full record

ArticleAMIA ... Annual Symposium proceedings. AMIA Symposium2024

Assessing the Seasonality of Lab Tests Among Patients with Alzheimer's Disease and Related Dementias in OneFlorida Data Trust.

Wenshan Han, Balu Bhasuran, Victorine Patricia Muse, Søren Brunak, Lifeng Lin, Karim Hanna, Yu Huang, Jiang Bian, Zhe He

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Article in AMIA ... Annual Symposium proceedings. AMIA Symposium, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Wenshan HanFlorida State University, Tallahassee, FL, USA.
Balu BhasuranFlorida State University, Tallahassee, FL, USA.
Victorine Patricia MuseUniversity of Copenhagen, Copenhagen, Denmark.
Søren BrunakUniversity of Copenhagen, Copenhagen, Denmark.
Lifeng LinUniversity of Arizona, Tucson, AZ, USA.
Karim HannaUniversity of South Florida, Tampa, FL, USA.
Yu HuangUniversity of Florida, Gainesville, FL, USA.
Jiang BianUniversity of Florida, Gainesville, FL, USA.
Zhe HeFlorida State University, Tallahassee, FL, USA.

Funding

Using social networks to map and evaluate team science across CTSA hubsUL1TR001427 · NCATS · UNIVERSITY OF FLORIDA · PI MITCHELL, DUANE A. · 2015 to 2024
$37.2M
Systematic Analysis of Clinical Study Generalizability Assessment Methods with InformaticsR21AG061431 · NIA · FLORIDA STATE UNIVERSITY · PI BIAN, JIANG, HE, ZHE · 2019 to 2020
$793k
AHRQ HHS R21 HS029969NCATS NIH HHS UL1 TR001427NIA NIH HHS R21 AG061431
6 · The paper itself

Abstract

About 1 in 9 older adults over 65 has Alzheimer's disease (AD), many of whom also have multiple other chronic conditions such as hypertension and diabetes, necessitating careful monitoring through laboratory tests. Understanding the patterns of laboratory tests in this population aids our understanding and management of these chronic conditions along with AD. In this study, we used an unimodal cosinor model to assess the seasonality of lab tests using electronic health record (EHR) data from 34,303 AD patients from the OneFlorida+ Clinical Research Consortium. We observed significant seasonal fluctuations-higher in winter in lab tests such as glucose, neutrophils per 100 white blood cells (WBC), and WBC. Notably, certain leukocyte types like eosinophils, lymphocytes, and monocytes are elevated during summer, likely reflecting seasonal respiratory diseases and allergens. Seasonality is more pronounced in older patients and varies by gender. Our findings suggest that recognizing these patterns and adjusting reference intervals for seasonality would allow healthcare providers to enhance diagnostic precision, tailor care, and potentially improve patient outcomes.

Indexed as

Alzheimer DiseaseClinical Laboratory TechniquesDementiaSeasonsAgedAged, 80 and overElectronic Health RecordsFemaleHumansMale

Identifiers

PMID40417579
PMCPMC12099435

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.