Evidence map›Paper›PMID 40417753›Full record

ArticleCurrent pharmaceutical biotechnology2026

Design and Preliminary

Harita Desai, Pranav Shah, Vikas Sawant, Rashmi Singh

Abstract read
PubMed Publisher
In one paragraph

Article in Current pharmaceutical biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Harita DesaiDepartment of Pharmaceutics, Bombay College of Pharmacy, Kollivery Village, Mathuradas Colony, Santacruz East, Mumbai, 400098, India.ORCID 0009-0007-9860-066X
Pranav ShahDepartment of Pharmaceutics, Maliba Pharmacy College, Surat, India.ORCID 0000-0003-1057-2566
Vikas SawantDepartment of Pharmaceutics, Bombay College of Pharmacy, Kollivery Village, Mathuradas Colony, Santacruz East, Mumbai, 400098, India.
Rashmi SinghDepartment of Pharmaceutics, Bombay College of Pharmacy, Kollivery Village, Mathuradas Colony, Santacruz East, Mumbai, 400098, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe inherent limitation of ocular dosage forms is decreased precorneal residence time which affects the bioavailability and therapeutic efficacy.

objectiveThe objective of the current research was to sustain drug release and enhance precorneal drug residence time by formulating lipidic core-shell nanoparticles of Dexamethasone Sodium Phosphate and loading them in ion-sensitive in situ gel for corneal neovascularization.

methodsPolymeric nanoparticles were formulated using Eudragit L100-55 and PVA by twostep solvent diffusión nanoprecipitation method and coated by a lipidic film of Soya phosphatidylcholine with Cholesterol. The optimized lipidic core-shell nanoparticles were transformed into

conclusionA decline in ex vivo drug permeation was observed through an aqueous suspension of core-shell polymeric nanoparticles and core-shell LPN loaded in situ gel thus confirming sustained release for the drug Dexamethasone Sodium Phosphate.

Indexed as

Corneal NeovascularizationDexamethasoneDrug CarriersNanoparticlesAnimalsDelayed-Action PreparationsDrug LiberationGelsParticle SizePolysaccharides, BacterialDelayed-Action PreparationsDexamethasonedexamethasone 21-phosphateDrug Carriersgellan gumGelsPolysaccharides, Bacterialdexamethasone sodium phosphateentrapment efficiencygellan gumin situ gelLipid core shell nanoparticlesnanoprecipitation

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.