ReviewMolecular medicine reports2025
Role of amino acid metabolism in osteoporosis: Effects on the bone microenvironment and treatment strategies (Review).
Review in Molecular medicine reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Age-related GSS promoter methylation in BMSCs drives osteoporosis and the reversal by targeted GSH delivery.Bioactive materials · 2026Article
- Branched‑chain amino acid metabolism and bone metabolism: Implications for osteoporosis pathogenesis and therapeutic strategies (Review).International journal of molecular medicine · 2026Review
- Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteoporosis is a metabolic disease characterized by an imbalance in bone remodeling. Its pathogenesis involves a functional imbalance of osteoblasts, osteoclasts and bone marrow mesenchymal stem cells. Amino acid metabolism is a key biochemical process for maintaining biological activities, including protein synthesis, energy supply and signal transduction. Amino acid metabolism affects bone homeostasis by regulating osteocyte function and the bone microenvironment. Branched‑chain amino acid and aromatic amino acid metabolism are involved in the regulation of bone mineral density. The present review demonstrates the mechanism of amino acid metabolism in osteoporosis and its potential therapeutic value. In addition, the present review aimed to summarize the application of Mendelian randomization and metabolomic methods to provide a reference for future research and clinical interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.