ArticleBrain and behavior2025
The Causal Relationship Between Asthma and Hippocampal Volume: A Study Based on Bidirectional Mendelian Randomization Analysis.
Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Brain pathology in relation to somatic diseases: Exploring the body-brain crosstalk.Journal of internal medicine · 2026Review
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Abstract
backgroundAsthma is a common chronic respiratory disease, and its potential association with the central nervous system has garnered increasing attention in recent years. While observational studies suggest that asthma may affect hippocampal structure and function through mechanisms such as chronic inflammation and hypoxia, its causal relationship remains unclear.
methodsIn this study, we employed a two-sample Mendelian randomization (MR) analysis, utilizing large-scale genome-wide association study (GWAS) data to systematically investigate the potential causal relationship between asthma and hippocampal volume. Data from a GWAS of asthma involving 155,386 individuals of European ancestry and GWAS imaging-derived phenotypes (IDPs) of hippocampal volume from 33,219 European individuals were analyzed.
resultsThe results revealed a significant negative correlation between asthma and multiple hippocampal IDPs (P
conclusionOur study provides genetic evidence for a causal relationship between asthma and changes in hippocampal volume, highlighting the need for closer monitoring and intervention in the neurocognitive health of asthma patients in clinical practice. Future studies should explore the causal relationship between asthma and brain structural changes across different racial groups and asthma subtypes, as well as the underlying biological mechanisms.
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