Evidence map›Paper›PMID 40418143›Full record

Trial reportBrain and behavior2025

Effects of Repetitive Transcranial Magnetic Stimulation on Upper Limb Motor Function and Serum Lipid Metabolomics in Patients With Ischemic Stroke: A Randomized Controlled Study.

Meng-Meng Li, Fei-Yang Jia, Peng-Cheng Liu, Hong-Ya Liu, Gui-Juan Zhou, Xin-Ke Peng, Jin-Ling Wang, Shu-Zhi Li, Jing Liu, Jun Zhou

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Meng-Meng LiThe First Affiliated Hospital, Rehabilitation Medicine Center, Hengyang Medical School, University of South China, Hengyang, Hunan, China.ORCID https://orcid.org/0009-0007-0623-4288
Fei-Yang JiaThe Affiliated Nanhua Hospital, Department of Rehabilitation, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Peng-Cheng LiuThe First Affiliated Hospital, Rehabilitation Medicine Center, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Hong-Ya LiuThe First Affiliated Hospital, Rehabilitation Medicine Center, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Gui-Juan ZhouThe First Affiliated Hospital, Rehabilitation Medicine Center, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Xin-Ke PengThe First Affiliated Hospital, Rehabilitation Medicine Center, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Jin-Ling WangThe First Affiliated Hospital, Rehabilitation Medicine Center, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Shu-Zhi LiThe First Affiliated Hospital, Rehabilitation Medicine Center, Hengyang Medical School, University of South China, Hengyang, Hunan, China.
Jing LiuThe First Affiliated Hospital, Rehabilitation Medicine Center, Hengyang Medical School, University of South China, Hengyang, Hunan, China.ORCID https://orcid.org/0000-0003-3433-364X
Jun ZhouThe First Affiliated Hospital, Rehabilitation Medicine Center, Hengyang Medical School, University of South China, Hengyang, Hunan, China.ORCID https://orcid.org/0000-0001-8280-6822

Funding

Clinical Research 4310 Program of the First Affiliated Hospital of the University of South China 20214310NHYCG07National Natural Science Foundation of China 82305403Natural Science Foundation of Hainan Province 2021JJ30617Natural Science Foundation of Hainan Province 2023JJ40592Natural Science Foundation of Hainan Province 2024JJ5356
6 · The paper itself

Abstract

introductionRepetitive transcranial magnetic stimulation (rTMS) can reduce upper extremity motor dysfunction in patients with stroke. However, the optimal parameters and mechanisms of rTMS in stroke treatment remain unclear. Therefore, this study aimed to investigate the protective effect and mechanism of rTMS at different frequencies on the motor function of the upper limbs in patients with cerebral infarction using lipid metabolomics methods.

methodsA total of 102 participants were randomly assigned to receive sham rTMS, 1 Hz rTMS, and 10 Hz rTMS. All participants were assessed at baseline and 2 weeks later using the Fugl-Meyer Assessment upper extremity (FMA-UE), National Institutes of Health Stroke Scale (NIHSS), Barthel scales, and serum collection-lipid metabolomics analysis of serum samples by untargeted metabolomics.

resultsThe improvement in FMA-UE, NIHSS, and Barthel scores was more significant in 1 and 10 Hz rTMS groups than in the sham rTMS treatment group (p < 0.05). The improvement effect of FMA-UE (p < 0.05) and Barthel (p < 0.05) was significantly more potent with 1 Hz rTMS than with 10 Hz rTMS. There was no significant difference in NHISS (p > 0.05). After rTMS treatment of patients with ischemic stroke, differential metabolites of serum lipids included diacylglycerol phosphoinositide, triacylglycerol, and dialkyl glycerol.

conclusionBoth low- and high-frequency rTMS can effectively improve upper limb motor function and self-care ability in patients with ischemic stroke. However, the effect of low-frequency rTMS on improving upper limb motor function was more significant. Lipid metabolomics analysis revealed that high- and low-frequency rTMS increased diacylglycerol phosphoinositide and triacylglycerol levels and reduced dialkyl glycerol levels.

Indexed as

Ischemic StrokeLipidsStroke RehabilitationTranscranial Magnetic StimulationUpper ExtremityAgedFemaleHumansMaleMetabolomicsMiddle AgedTreatment OutcomeLipidsischemic stroke | lipidomics | repetitive transcranial magnetic stimulation | upper limb motor dysfunction

Identifiers

PMID40418143
PMCPMC12105109

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.