Evidence map›Paper›PMID 40418314›Full record

ArticleApplied biochemistry and biotechnology2025

Coproduction of Glutathione and 5-Aminolevulinic Acid by Saccharomyces cerevisiae NMZ-2 on Spent Coffee Grounds.

Natsuki T Kawachi, Yoko Hirono-Hara, Hiroshi Kikukawa, Hiroshi Takagi, Masatoshi Hakamata, Kiyotaka Y Hara

Abstract read
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Article in Applied biochemistry and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Natsuki T KawachiGraduate Division of Nutritional and Environmental Sciences, University of Shizuoka, 52-1 Yada, Suruga-Ku, Shizuoka, 422-8526, Japan.
Yoko Hirono-HaraDepartment of Environmental and Life Sciences, School of Food and Nutritional Sciences, University of Shizuoka, 52-1 Yada, Suruga-Ku, Shizuoka, 422-8526, Japan.
Hiroshi KikukawaGraduate Division of Nutritional and Environmental Sciences, University of Shizuoka, 52-1 Yada, Suruga-Ku, Shizuoka, 422-8526, Japan.
Hiroshi TakagiNumazu Technical Support Center, Industrial Research Institute of Shizuoka Prefecture, 3981-1 Ohoka, Numazu, Shizuoka, 410-0022, Japan.
Masatoshi HakamataNumazu Technical Support Center, Industrial Research Institute of Shizuoka Prefecture, 3981-1 Ohoka, Numazu, Shizuoka, 410-0022, Japan.
Kiyotaka Y HaraGraduate Division of Nutritional and Environmental Sciences, University of Shizuoka, 52-1 Yada, Suruga-Ku, Shizuoka, 422-8526, Japan. k-hara@u-shizuoka-ken.ac.jp.ORCID http://orcid.org/0000-0002-4477-6594

Funding

JSPS JP21H03645
6 · The paper itself

Abstract

Large amounts of spent coffee grounds (SCGs) are generated daily around the world. SCGs can be partly used for fertilizer production by composting through multiple microbial fermentations. In the coffee biorefinery, an attractive way to add value to the SCGs fertilizer is by producing additional biostimulants. In this study, glutathione (GSH) and 5-aminolevulinic acid (5-ALA), biostimulants for agriculture, were coproduced by fermentation of a yeast, Saccharomyces cerevisiae NMZ-2, with spent coffee grounds extract (SCGE). The addition of SCGE promoted the growth of this strain and the production of GSH and 5-ALA. This study indicated that SCGE contained carbon and nitrogen sources and minerals for the S. cerevisiae NMZ-2. Controlling the amount of glycine could regulate the ratio of GSH and 5-ALA production. Biostimulants containing a favorable ratio of GSH and 5-ALA produced by the S. cerevisiae NMZ-2 using SCGE would be applicable in a coffee biorefinery.

Indexed as

Aminolevulinic AcidCoffeeGlutathioneSaccharomyces cerevisiaeFermentationAminolevulinic AcidCoffeeGlutathioneBioeconomyBiomassBiostimulantFood wasteUpcycleYeast

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.