Evidence map›Paper›PMID 40418340›Full record

Trial reportEuropean journal of nutrition2025

A randomized controlled cross-over trial of differences in acute effects on serum metabolites from isocaloric meals based on red meat, fatty fish, or soy protein.

Helen M Lindqvist, Erik Hulander, Linnea Bärebring, Inger Gjertsson, Anna Winkvist

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04247009 (Postprandial Inflammation in Rheumatoid Arthritis), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04247009 nacompletednot on this map

Postprandial Inflammation in Rheumatoid Arthritis

TypeinterventionalSponsorGöteborg UniversityRan2020 to 2021Enrolled56ConditionsArthritis, Rheumatoid, Inflammatory Response, Dietary Exposure, Diet, HealthyArmsMeal based on red meat, fish products or vegan products, Meal based on red meat
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Helen M LindqvistDepartment of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, PO Box 459, Gothenburg, SE-405 30, Sweden. helen.lindqvist@gu.se.ORCID http://orcid.org/0000-0002-2627-0434
Erik HulanderDepartment of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, PO Box 459, Gothenburg, SE-405 30, Sweden.ORCID http://orcid.org/0000-0003-3416-2748
Linnea BärebringDepartment of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, PO Box 459, Gothenburg, SE-405 30, Sweden.ORCID http://orcid.org/0000-0002-1612-1697
Inger GjertssonDepartment of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.ORCID http://orcid.org/0000-0002-9301-4844
Anna WinkvistDepartment of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, PO Box 459, Gothenburg, SE-405 30, Sweden.ORCID http://orcid.org/0000-0001-9122-7240

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeReducing red meat intake in the Western diet is beneficial for health and the environment. However, red meat is nutrient-rich, so understanding the impact of substituting it with other protein sources such as fish or plant-based proteins is essential, especially for vulnerable groups like the elderly and those with chronic diseases. The purpose of this study was to study the postprandial response in serum metabolites in women with Rheumatoid Arthritis (RA) after intake of red meat, fatty fish, and soy protein.

methodsWomen with RA (n = 24) consumed isocaloric meals that included burgers made from either red meat, fatty fish, or soy protein in a crossover design. Blood samples were taken in fasting state before the meal (0 h) and at intervals up to 5 h after eating. Nuclear Magnetic Resonance (NMR) analysis quantified serum metabolites, and multivariate models and univariate statistics were applied to compare postprandial metabolite changes across protein sources.

resultsPostprandial metabolite patterns varied significantly by protein type. The fatty fish meal led to a faster and higher increase in metabolites, including creatinine, isoleucine, valine, and trimethylamine N-oxide, compared to red meat. Unidentified lipids also differed. However, metabolite patterns after soy protein were similar to those after red meat.

conclusionThis postprandial crossover trial found that intake of fatty fish lead to a quicker and more pronounced increase in key blood concentrations of metabolites compared to red meat. However, metabolite profiles in serum based on NMR-analysis were similar after intake of soy protein compared to red meat.

trial registrationThe PIRA (Postprandial Inflammation in Rheumatoid Arthritis) trial is Registered at Clinicaltrials.gov (NCT04247009).

Indexed as

Dietary FatsRed MeatSoybean ProteinsAdultAgedAnimalsArthritis, RheumatoidCreatinineCross-Over StudiesDietDietary ProteinsFemaleHumansMealsMethylaminesMiddle AgedCreatinineDietary FatsDietary ProteinsMethylaminesSoybean ProteinstrimethyloxamineFatty fishMetabolomicsPostprandialRed meatRheumatoid arthritisSoy

Identifiers

PMID40418340
PMCPMC12106552

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.