Evidence map›Paper›PMID 40418506›Full record

Trial reportGeroScience2026

Effects of aerobic exercise and cardiorespiratory fitness on white matter free water fraction in older adults: a 1-year randomized controlled trial.

Takashi Tarumi, Junyeon Won, Tsubasa Tomoto, Norman Scheel, David C Zhu, John Ashley, Karen M Rodrigue, Kristen M Kennedy, Denise C Park, Rong Zhang

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Takashi TarumiNational Institute of Advanced Industrial Science and Technology, Integrated Research Center for Self-Care Technology, Tsukuba, Ibaraki, Japan.
Junyeon WonInstitute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, TX, USA.
Tsubasa TomotoNational Institute of Advanced Industrial Science and Technology, Integrated Research Center for Self-Care Technology, Tsukuba, Ibaraki, Japan.
Norman ScheelDepartment of Radiology and Cognitive Imaging Research Center, Michigan State University, East Lansing, MI, USA.
David C ZhuDepartment of Radiology and Cognitive Imaging Research Center, Michigan State University, East Lansing, MI, USA.
John AshleyInstitute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, TX, USA.
Karen M RodrigueCenter for Vital Longevity, School of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, TX, USA.
Kristen M KennedyCenter for Vital Longevity, School of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, TX, USA.
Denise C ParkCenter for Vital Longevity, School of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, TX, USA.
Rong ZhangInstitute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, TX, USA. RongZhang@TexasHealth.org.ORCID 0000-0002-6534-5216

Funding

Japan Society for the Promotion of Science 23K24748NIA NIH HHS R01-HL-102457
6 · The paper itself

Abstract

Free water fraction (FWF), derived from diffusion MRI, is a sensitive biomarker of white matter microstructure and may be modifiable through lifestyle interventions. The mid-anterior corpus callosum (CC) has been proposed as particularly responsive to physical exercise and the related increases in cardiorespiratory fitness. This study examined the effects of aerobic exercise training and fitness on FWF in the CC and on cognitive performance in older adults. Seventy-three participants (mean age 69 ± 5 years, 77% women) were randomized to a 1-year aerobic training or stretching intervention. FWF was assessed using diffusion tensor MRI, fitness via maximal oxygen uptake (VO

Indexed as

Cardiorespiratory FitnessCorpus CallosumExerciseWhite MatterAgedCognitionDiffusion Tensor ImagingFemaleHumansMaleMiddle AgedOxygen ConsumptionAerobic exerciseCardiorespiratory fitnessCognitive functionFree waterWhite matter

Identifiers

PMID40418506
PMCPMC12972341

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.