Evidence mapPaperPMID 40418622Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2025

Jayson M Antonio, Yue Liu, Panan Suntornsaratoon, Abigail Jones, Jayanth Ambat, Ajitha Bala, Joshua Joby Kanattu, Juan Flores, Sheila Bandyopadhyay, Ravij Upadhyay and 5 more

Abstract read
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Nutrient control enables metabolic reconstruction ofbioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Jayson M AntonioDepartment of Pharmacology, Physiology and Neurosciences, New Jersey Medical School, Rutgers University, Newark, New Jersey, United States.ORCID 0000-0001-6855-5617
Yue LiuDepartment of Biological Sciences, Rutgers University, Newark, New Jersey, United States.
Panan SuntornsaratoonDepartment of Pharmacology, Physiology and Neurosciences, New Jersey Medical School, Rutgers University, Newark, New Jersey, United States.
Abigail JonesDepartment of Pharmacology, Physiology and Neurosciences, New Jersey Medical School, Rutgers University, Newark, New Jersey, United States.
Jayanth AmbatDepartment of Pharmacology, Physiology and Neurosciences, New Jersey Medical School, Rutgers University, Newark, New Jersey, United States.
Ajitha BalaDepartment of Pharmacology, Physiology and Neurosciences, New Jersey Medical School, Rutgers University, Newark, New Jersey, United States.
Joshua Joby KanattuDepartment of Pharmacology, Physiology and Neurosciences, New Jersey Medical School, Rutgers University, Newark, New Jersey, United States.ORCID 0009-0001-9061-174X
Juan FloresDepartment of Biological Sciences, Rutgers University, Newark, New Jersey, United States.
Sheila BandyopadhyayDepartment of Biological Sciences, Rutgers University, Newark, New Jersey, United States.ORCID 0000-0002-1827-9324
Ravij UpadhyayDepartment of Pharmacology, Physiology and Neurosciences, New Jersey Medical School, Rutgers University, Newark, New Jersey, United States.
Jagannatham Naidu BhupanaDepartment of Pharmacology, Physiology and Neurosciences, New Jersey Medical School, Rutgers University, Newark, New Jersey, United States.ORCID 0009-0009-3304-5831
Xiaoyang SuDepartment of Medicine, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, New Jersey, United States.ORCID 0000-0001-8081-1396
Wei Vivian LiDepartment of Statistics, University of California, Riverside, Riverside, California, United States.ORCID 0000-0002-2087-2709
Nan GaoDepartment of Pharmacology, Physiology and Neurosciences, New Jersey Medical School, Rutgers University, Newark, New Jersey, United States.
Ronaldo P FerrarisDepartment of Pharmacology, Physiology and Neurosciences, New Jersey Medical School, Rutgers University, Newark, New Jersey, United States.ORCID 0000-0001-6887-5020

Funding

Physiological Regulation of Intestinal PermeabilityR01DK061931 · UNIVERSITY OF CHICAGO · 2001 to 2025
$2.3M
Paneth cell heterogeneity in infection and inflammationR01DK132885 · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · 2025 to 2025
$468k
Novel Statistical Methods for Multiscale Analysis of Single-cell TranscriptomesR35GM142702 · UNIVERSITY OF CALIFORNIA RIVERSIDE · 2025 to 2025
$389k
HHS | National Institutes of Health (NIH) R01-AT010243HHS | National Institutes of Health (NIH) R01DK06193HHS | National Institutes of Health (NIH) R01DK102934HHS | National Institutes of Health (NIH) R01DK119198HHS | National Institutes of Health (NIH) R35GM142702HHS | NIH | National Cancer Institute (NCI) NCI-CCSG P30CA072720-5923National Science Foundation (NSF) 1952823National Science Foundation (NSF) IOS 1754783NCCIH NIH HHS R01 AT010243NIDDK NIH HHS F31 DK121428NIDDK NIH HHS R01 DK061931NIDDK NIH HHS R01 DK102934NIDDK NIH HHS R01 DK119198NIDDK NIH HHS R01 DK132885NIGMS NIH HHS R35 GM142702
6 · The paper itself

Abstract

Inflammatory bowel diseases (IBDs) and gut barrier impairment are associated with changes in dietary tryptophan and arginine metabolism, but mechanisms of barrier perturbation and restoration are unclear. We show here that the widely consumed probiotic

Indexed as

ArginineColitisGastrointestinal MicrobiomeInflammatory Bowel DiseasesIntestinal MucosaLacticaseibacillus rhamnosusProbioticsAnimalsArgininosuccinate LyaseFemaleHumansMaleMiceMice, Inbred C57BLNitric Oxide Synthase Type IITryptophanArginineArgininosuccinate LyaseNitric Oxide Synthase Type IITryptophaninflammatory bowel diseaseintestineprobioticstight junctiontryptophan

Identifiers

PMID40418622
PMCPMC12282327

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.