ArticleClinical and experimental otorhinolaryngology2025
Functional and Morphological Changes in the Olfactory Epithelium of Mouse Models With Upper Respiratory Inflammation and Olfactory Dysfunction.
Article in Clinical and experimental otorhinolaryngology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Article
- Global research trends and hotspot evolution of olfactory dysfunction from 2014 to 2024: a bibliometric analysis.Annals of medicine and surgery (2012) · 2026Review
- Sensory changes in the chin and lower lip after transoral endoscopic thyroidectomy.Surgical endoscopy · 2026Observational
- Olfactory epithelium organoid models identify Ddit3 as a potential therapeutic target against inflammation-related olfactory sensory neuronal loss and functional deficit.International journal of biological sciences · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
objectivesThis study evaluated behavioral test results and histological findings in murine models of allergic rhinitis (AR), chronic rhinosinusitis (CRS), and drug-induced anosmia, comparing outcomes among groups.
methodsThis study established a total of six animal model groups (n=5 per group): control; ovalbumin (OVA)-induced AR; OVA/polyinosinic-polycytidylic acid (poly[I:C])-induced neutrophil-dominant rhinitis; OVA/Staphylococcus enterotoxin B-induced CRS; and two anosmia models induced by chronic intranasal administration of ZnSO4 and intraperitoneal injection of 3-methylindole (3-MI). Olfactory function was evaluated using an open-field food-finding test and a T-maze test one week after model induction. Behavioral test results were analyzed with video analysis software (EthoVision XT). Immunofluorescent staining was conducted to assess histological changes in olfactory sensory neurons (OSNs) and olfactory basal cells.
resultsIn the T-maze test, the OVA and OVA/poly(I:C)-induced rhinitis groups showed increased food-finding time compared with the control and CRS groups. The two anosmia mouse models demonstrated statistically significant differences from all other groups. Food-finding time showed significant positive correlations with two novel variables evaluated in this study: total distance moved and average velocity, in both the open-field and T-maze tests. Histologically, the CRS and two anosmia models exhibited a significant decrease in mature and immature OSNs. Additionally, the two rhinitis groups and the CRS group displayed significant changes in the number of immature OSNs. Changes in the basal cell marker cytokeratin-5 were observed specifically in the 3-MI model.
conclusionThis study demonstrated significant differences in olfactory function and histological changes among various mouse models of upper airway inflammation and drug-induced anosmia, as assessed by histological analysis and behavioral tests. These findings can serve as a reference for future studies on olfaction using mouse models.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.