ArticleScientific reports2025
Enhanced colon-targeted drug delivery through development of 5-fluorouracil-loaded cross-linked mastic gum nanoparticles.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Protein-Modulated Stimuli-Responsive Hydrogels Based on Methacrylated Bovine Serum Albumin and pNIPAm: pH- and Temperature-Dependent Drug Release Behavior.Gels (Basel, Switzerland) · 2026Article
- Cyclodextrin-Based Nanocarriers for 5-Fluorouracil: Cholesteryl Modification Enhances Antitumor Activity Against Colorectal Cancer Cells.International journal of nanomedicine · 2026Article
- Recent Advances and Future Directions in 5-Fluorouracil Drug Delivery: A Comprehensive Review.Current topics in medicinal chemistry · 2026Review
- Breaking the Alzheimer's Treatment Stalemate: Synergistic Application Strategies of Nanomaterials and Pharmaceutical Agents.Molecular neurobiology · 2025Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
This study explored the development of a novel colon-specific drug delivery system for 5-fluorouracil (5-FU) using cross-linked mastic gum (MG) nanoparticles (NPs). The primary goal is to enhance the treatment efficacy of colon cancer while minimizing systemic side effects. We employed Fourier Transform Infrared Radiation (FTIR) and Scanning Electron Microscopy (SEM) for the detailed characterization of the samples. FTIR analysis confirmed the successful cross-linking of MG, whereas SEM images revealed the spherical and uniform morphology of the NPs. Additionally, analysis of drug encapsulation efficiency (83.53%), particle size (240 nm), and drug release kinetics (zero-order), and the drug release percentage (95.20% ) were analyzed. The results demonstrated that MG NPs effectively encapsulated and controlled the release of 5-FU in a colon-targeted manner. This study recommends the proposed drug delivery system because of its potential to improve the outcomes of colon cancer treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.