Evidence map›Paper›PMID 40419683›Full record

ArticleScientific reports2025

Profiling protein hydrolysis and amino acid metabolism in camel and bovine milk fermented by Lactobacillus helveticus, L. bulgaricus, and Streptococcus thermophilus.

Santhoshani Warakaulle, Mutamed M Ayyash, Afaf Kamal-Eldin

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Santhoshani WarakaulleDepartment of Food Science, College of Agriculture and Veterinary Medicine, United Arab Emirates University, P.O. Box 15551, Al Ain, United Arab Emirates.
Mutamed M AyyashDepartment of Food Science, College of Agriculture and Veterinary Medicine, United Arab Emirates University, P.O. Box 15551, Al Ain, United Arab Emirates.
Afaf Kamal-EldinDepartment of Food Science, College of Agriculture and Veterinary Medicine, United Arab Emirates University, P.O. Box 15551, Al Ain, United Arab Emirates. Afaf.Kamal@uaeu.ac.ae.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fermented milk has received significant attention due to its multiple health benefits. The fermentation of milk is a complex and dynamic process that is greatly affected by the selection of the starter cultures. This study examined the impacts of mono- and co-fermentation involving Lactobacillus helveticus, L. delbrueckii subsp. bulgaricus, and Streptococcus salivarius subsp. thermophilus on proteolysis and amino acid metabolism in camel milk (CM) and bovine milk (BM). Fermentation of CM was accompanied by more degradation of caseins and formation of free amino groups compared with BM. Two-way ANOVA analysis showed that residual caseins and free amino group content are affected by bacteria, milk type, and their interactions (p < 0.001). Metabolomic analysis revealed variations in the amino acid metabolites between CM and BM including 12 free amino acids, 13 dipeptides, 12 tri- and higher peptides, and 7 lactoyl amino acids. Importantly, proline-rich peptides, known for their angiotensin-converting enzyme (ACE) inhibitory activity, were more abundant in CM and BM fermented with L. helveticus. These insights into milk differences and proteolytic system variations across bacterial cultures support the selection of strains with enhanced metabolic potential for fermented functional foods.

Indexed as

Amino AcidsLactobacillusLactobacillus helveticusMilkMilk ProteinsStreptococcus thermophilusAnimalsCamelusCattleFermentationHydrolysisLactobacillus delbrueckiiProteolysisAmino AcidsMilk ProteinsACE inhibitory peptidesAmino acid metabolitesBovine milkCamel milkFermentationProtein hydrolysis

Identifiers

PMID40419683
PMCPMC12106841

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.