Evidence map›Paper›PMID 40419688›Full record

ArticleLung2025

Role of Slc7a11 in Bleomycin-Induced Lung Injury.

Jeffrey D Ritzenthaler, Edilson Torres-Gonzalez, Yvonne Janssen-Heininger, Walter H Watson, Jesse Roman

Abstract read
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In one paragraph

Article in Lung, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jeffrey D RitzenthalerDepartment of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA, USA.
Edilson Torres-GonzalezDepartment of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA, USA.
Yvonne Janssen-HeiningerDepartment of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, VT, USA.
Walter H WatsonDepartment of Medicine, Division of Gastroenterology, Hepatology & Nutrition, University of Louisville School of Medicine, Louisville, KY, USA.
Jesse RomanDepartment of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA, USA. Jesse.roman@jefferson.edu.

Funding

NIH HHS 1R01HL147088
6 · The paper itself

Abstract

Oxidative stress has been implicated in lung injury and repair. We seek to understand how alterations in the plasma redox potential (Eh) of the thiol disulfide couple cysteine (Cys) and cystine (CySS) (Eh Cys/CySS) affect this process. Previously, we reported that Eh Cys/CySS oxidation promotes a pro-fibrotic phenotype in lung fibroblasts and identified the cystine/glutamate exchanger solute carrier family 7, member 11 (Slc7a11) as a regulator of Eh Cys/CySS. We also observed that pharmacological agents capable of altering Slc7a11 expression affect lung fibroblast phenotype in vitro. We hypothesized that alterations in Slc7a11 expression would affect lung injury in vivo and set out to test this in C57Bl6 mice exposed to bleomycin. However, we did not observe changes in bleomycin-induced lung injury in animals treated with pharmacological alterations in Slc7a11 expression or when Slc7a11 knockout animals were tested. Thus, the role of Slc7a11 in lung injury remains uncertain.

Indexed as

Amino Acid Transport System y+LungLung InjuryAnimalsBleomycinCysteineCystineDisease Models, AnimalFibroblastsMaleMiceMice, Inbred C57BLMice, KnockoutOxidative StressPulmonary FibrosisAmino Acid Transport System y+BleomycinCysteineCystineSlc7a11 protein, mouseLung injuryOxidative stressRedox

Identifiers

PMID40419688

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.