Evidence map›Paper›PMID 40419964›Full record

ArticleBMC gastroenterology2025

CD45

Nan Zhang, Hai-Shi Wu, Xiu-Qing Pang, Cheng-You Yu, Xing Li, Zhi-Liang Gao

Abstract read
In one paragraph

Article in BMC gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Acute-on-chronic liver failure-associated CD45Cellular and molecular life sciences : CMLS · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nan Zhang *Department of Infectious Diseases, The Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, China.
Hai-Shi Wu *Department of Infectious Diseases, The Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, China.
Xiu-Qing Pang *Department of Infectious Diseases, The Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, China.
Cheng-You YuDepartment of Infectious Diseases, The Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, China.
Xing LiGuangdong Key laboratory of Liver Disease Research, The Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, China. lixing9@mail.sysu.edu.cn.
Zhi-Liang GaoDepartment of Infectious Diseases, The Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, China. gaozhl@mail.sysu.edu.cn.

Funding

Guangzhou Science and Technology Program Key Projects 2023B01J1007National Natural Science Foundation of China,China 82170612
6 · The paper itself

Abstract

backgroundHepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is characterized by immune dysregulation and systemic inflammation, which lead to high mortality. Although immunosuppressive CD45

methodsIn this retrospective study, we analyzed the data of 102 patients with CHB and 65 patients with HBV-ACLF receiving standard drugs treatment from the Third Affiliated Hospital of Sun Yat-sen University between January 2021 and December 2023. HBV-ACLF diagnosis followed the Chinese Group on the Study of Severe Hepatitis B-Acute-on-Chronic Liver Failure criteria, with strict exclusion of comorbidities. Peripheral blood mononuclear cells (PBMCs) were isolated via density gradient centrifugation, and CD45

resultsOur findings revealed that patients with HBV-ACLF had significantly elevated percentages of CD45

conclusionsThe percentage of CD45

Indexed as

Acute-On-Chronic Liver FailureErythroid Precursor CellsHepatitis B, ChronicLeukocyte Common AntigensAdultBiomarkersDisease ProgressionFemaleHumansMaleMiddle AgedPrognosisRetrospective StudiesBiomarkersLeukocyte Common AntigensPTPRC protein, humanAcute-on-chronic liver failureBiomarkerCD45+ erythroid progenitor cellsDisease progressionLogistic regression

Identifiers

PMID40419964
PMCPMC12105192

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.