Evidence mapPaperPMID 40420106Full record

ArticleJournal of nanobiotechnology2025

Multifunctional hydrogel with mild photothermal properties enhances diabetic wound repair by targeting MRSA energy metabolism.

Qian Gao, Fangfang Hu, Zihan Chai, Caiyun Zheng, Wenhui Zhang, Ke Pu, Ziyi Yang, Yanni Zhang, Seeram Ramrkrishna, Xianglong Wu and 1 more

Abstract read
In one paragraph

Article in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Review
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  4. NbAdvanced healthcare materials · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
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  14. Pharmacological and Biological Efficacy of Chitosan-Based Materials.International journal of molecular sciences · 2025
    Review
  15. Article
  16. Review
  17. Carbon nanotubes for wound healing: material design, mechanistic insights.Frontiers in bioengineering and biotechnology · 2025
    Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Qian GaoKey Laboratory of Space Bioscience and Biotechnology, Engineering Research Center of Chinese Ministry of Education for Biological Diagnosis, Treatment and Protection Technology and Equipment, School of Life Sciences, Northwestern Polytechnical University, No. 1 Dongxiang Road, Chang'an District, Xi'an City, 710129, People's Republic of China.
Fangfang HuKey Laboratory of Space Bioscience and Biotechnology, Engineering Research Center of Chinese Ministry of Education for Biological Diagnosis, Treatment and Protection Technology and Equipment, School of Life Sciences, Northwestern Polytechnical University, No. 1 Dongxiang Road, Chang'an District, Xi'an City, 710129, People's Republic of China.
Zihan ChaiKey Laboratory of Space Bioscience and Biotechnology, Engineering Research Center of Chinese Ministry of Education for Biological Diagnosis, Treatment and Protection Technology and Equipment, School of Life Sciences, Northwestern Polytechnical University, No. 1 Dongxiang Road, Chang'an District, Xi'an City, 710129, People's Republic of China.
Caiyun ZhengKey Laboratory of Space Bioscience and Biotechnology, Engineering Research Center of Chinese Ministry of Education for Biological Diagnosis, Treatment and Protection Technology and Equipment, School of Life Sciences, Northwestern Polytechnical University, No. 1 Dongxiang Road, Chang'an District, Xi'an City, 710129, People's Republic of China.
Wenhui ZhangKey Laboratory of Space Bioscience and Biotechnology, Engineering Research Center of Chinese Ministry of Education for Biological Diagnosis, Treatment and Protection Technology and Equipment, School of Life Sciences, Northwestern Polytechnical University, No. 1 Dongxiang Road, Chang'an District, Xi'an City, 710129, People's Republic of China.
Ke PuKey Laboratory of Space Bioscience and Biotechnology, Engineering Research Center of Chinese Ministry of Education for Biological Diagnosis, Treatment and Protection Technology and Equipment, School of Life Sciences, Northwestern Polytechnical University, No. 1 Dongxiang Road, Chang'an District, Xi'an City, 710129, People's Republic of China.
Ziyi YangKey Laboratory of Space Bioscience and Biotechnology, Engineering Research Center of Chinese Ministry of Education for Biological Diagnosis, Treatment and Protection Technology and Equipment, School of Life Sciences, Northwestern Polytechnical University, No. 1 Dongxiang Road, Chang'an District, Xi'an City, 710129, People's Republic of China.
Yanni ZhangKey Laboratory of Space Bioscience and Biotechnology, Engineering Research Center of Chinese Ministry of Education for Biological Diagnosis, Treatment and Protection Technology and Equipment, School of Life Sciences, Northwestern Polytechnical University, No. 1 Dongxiang Road, Chang'an District, Xi'an City, 710129, People's Republic of China.
Seeram RamrkrishnaDepartment of Mechanical Engineering, College of Design and Engineering, National University of Singapore, 21 Lower Kent Ridge Road, Singapore, 117574, Singapore.
Xianglong WuKey Laboratory of Space Bioscience and Biotechnology, Engineering Research Center of Chinese Ministry of Education for Biological Diagnosis, Treatment and Protection Technology and Equipment, School of Life Sciences, Northwestern Polytechnical University, No. 1 Dongxiang Road, Chang'an District, Xi'an City, 710129, People's Republic of China. wuxianglong@nwpu.edu.cn.
Tingli LuKey Laboratory of Space Bioscience and Biotechnology, Engineering Research Center of Chinese Ministry of Education for Biological Diagnosis, Treatment and Protection Technology and Equipment, School of Life Sciences, Northwestern Polytechnical University, No. 1 Dongxiang Road, Chang'an District, Xi'an City, 710129, People's Republic of China. lutinglixinxin@nwpu.edu.cn.

Funding

Innovation Foundation for Doctor Dissertation of Northwestern Polytechnical University CX2024081Natural Science Basic Research Program of Shaanxi Province 2023-JC-YB-290Natural Science Basic Research Program of Shaanxi Province 2024JC-YBMS-657
6 · The paper itself

Abstract

backgroundDiabetic wound infections, exacerbated by multidrug-resistant pathogens like MRSA, remain a critical challenge due to biofilm persistence and dysregulated oxidative-inflammatory-metabolic crosstalk.

resultsIn this work, we engineered COG-Z@P200 hydrogel, a chitosan-based hydrogel integrating polydopamine-coated ZIF-8 nanoparticles, to synergize mild photothermal therapy (40-45 °C) with metabolic-immune reprogramming. Upon NIR irradiation, COG-Z@P200 disrupted MRSA through Zn

conclusionOur work established a biomaterial paradigm that concurrently targets pathogen vulnerabilities and restores tissue homeostasis, addressing the multidimensional complexity of chronic wounds.

Indexed as

Energy MetabolismHydrogelsMethicillin-Resistant Staphylococcus aureusWound HealingAnimalsAnti-Bacterial AgentsBiofilmsChitosanDiabetes Mellitus, ExperimentalIndolesMaleMiceNanoparticlesPhotothermal TherapyPolymersStaphylococcal InfectionsAnti-Bacterial AgentsChitosanHydrogelsIndolespolydopaminePolymersDiabetic wound microenvironmentMetabolic interferenceMultifunctional hydrogel dressingPhotothermal therapyZIF-8 nanoparticles

Identifiers

PMID40420106
PMCPMC12105145

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.