ArticleJournal of animal science and biotechnology2025
Intestinal inflammation disrupts energy metabolism in layer pullets: insights into energy partitioning and intestinal metabolomic profiling.
Article in Journal of animal science and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Effects of different dietary metabolizable energy levels on growth performance, liver metabolism, and gut microbiota in growing broilers.Poultry science · 2026Article
- Comparative lipidomics and NAD⁺ metabolism in pectoris muscle reveal a lean metabolic phenotype in Daweishan miniature chickens versus arbor acre broilers.Poultry science · 2026Article
- Dietary semen cuscuta improves laying performance by stabilizing mitochondria-associated membranes (MAMs) and inhibiting granulosa cell apoptosis in laying hens.Poultry science · 2026Article
- Integrated Stress Physiology and Mitigation Strategies for Heat Stress in Layer Chickens-Review.Animals : an open access journal from MDPI · 2026Review
- Respiratory efficiency and thermoregulatory responses of L-citrulline-supplemented broiler chickens under acute and chronic stress conditions.Frontiers in physiology · 2026Article
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Authors and funding
6 authors.
Funding
Abstract
backgroundIntestinal inflammation is an energy-consuming process that may alter energy supply and demand in poultry. During inflammation, the intestinal energy metabolic profile and the patterns of energy partitioning remain unclear. This study investigated the effects of intestinal inflammation on energy intake, heat production (HP), retained energy (RE) and intestinal energy metabolites in layer pullets.
methodsAfter 7 d dietary adaption, 32 "Jing Tint 6" layer pullets with average body weight (1,123.50 ± 8.55 g) were selected from 96 birds, and randomly assigned to two groups (CON: Control group, INFL: Inflammation group) with 8 replicates per group. Indirect calorimetry analysis was conducted over 7 d to determine HP and fasting HP (FHP). During this period, pullets in INFL group received 4 mL/d of 0.6 g/mL dextran sulfate sodium (DSS) via oral gavage to induce intestinal inflammation. After the calorimetry, intestinal tissues were collected post-euthanasia from one bird per replicate for morphological and mucosal metabolomic analysis.
resultsBirds exhibited significantly lower apparent metabolizable energy (AME) intake (P < 0.001) during intestinal inflammation, accompanied by compromised RE and RE as fat (P < 0.001), suggesting that birds consumed body energy to sustain energy demands. Targeted metabolomic studies identified 11 energy metabolites differentially expressed in ileal mucosa between CON and INFL groups. Specifically, DSS induction significantly increased (P < 0.05) adenosine triphosphate (ATP) level and reduced (P < 0.001) nicotinamide adenine dinucleotide (NAD
conclusionImmune stimulation by DSS induced a negative energy balance in layer pullets, characterized by reduced AME intake (-190.47 kJ/kg BW
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