Trial reportBMC oral health2025
Is injectable platelet-rich fibrin really effective in alveolar osteitis? a randomised controlled clinical trial.
Trial report in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06761001 (Investigation of the Effect of I-PRF Application on Pain in Alveolitis), which is not on this map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Investigation of the Effect of I-PRF Application on Pain in Alveolitis
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Analgesic effects of platelet-rich fibrin (PRF): A systematic review.Periodontology 2000 · 2025Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlveolar osteitis(AO) is an inflammatory and painful condition that occurs due to distruption of the fibrin matrix within the extraction socket following tooth extraction. This study investigates the effectiveness of I-PRF in reducing pain in AO patients compared to conventional treatment. MATERIALS AND
methodsThis prospective randomized controlled study included patients experiencing localized AO treated at the Oral, Dental, and Maxillofacial Surgery clinic between October 2024 and February 2025. Sixty patients diagnosed with AO were randomly assigned to two groups. The control group (Group 1) received standard treatment consisting of socket curettage followed by saline irrigation. The I-PRF group (Group 2) received I-PRF application after curettage and irrigation. Pain levels were assessed using the Visual Analog Scale (VAS) on postoperative days 3 and 7.
resultsThe study included 60 patients (28 males, 32 females) aged between 19 and 68 (mean 37.40 ± 12.81). There was no significant difference in preoperative VAS scores between the groups (p>0.05). On postoperative day 7, the I-PRF group showed a significant reduction in VAS scores compared to the control group (1.27 vs. 2.27, p<0.05). Our results show that I-PRF significantly reduces pain levels, offering a promising alternative to traditional therapies.
conclusionI-PRF significantly reduces pain in AO patients compared to conventional treatment. These findings suggest that I-PRF could be a valuable addition to clinical practice, but further studies are needed to confirm its long-term effectiveness.
trial registrationClinical Trials.gov Registration ID NCT06761001. Registered 30/12/ 2024- Retrospectively registered.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.