Oral supplement in healthy older adults to support physical fitness and mental wellbeing.

Introduction: Cucumbers have been anecdotally credited with anti-inflammatory properties. IdoBR1 [(2 Methods: A healthy middle-aged and older adult population was recruited and randomized to receive either Q-actin™ (2 × gummies containing 10 mg Q-actin™ daily) or matched placebo gummies for 12 weeks. Physical strength and finger dexterity were assessed using hand grip strength and the Nine-Hole Peg Test, respectively. We evaluated diet choices with the Prime Diet Quality Score and sleep quality with the Pittsburgh Sleep Quality Index and collected first-morning urine samples for chemical composition analysis using Flow Infusion Electrospray Ionization Mass Spectrometry (FIE-MS). Results: We recruited a cohort of 47 healthy middle-aged and older adults (ages 50-78; 15 men and 32 women). FIE-MS analysis on urines was conducted and we tentatively identified elevated melatonin derivatives after Q-actin™ supplementation, suggesting a positive effect on sleep quality, which correlated with self-reported Pittsburgh Sleep Quality Index. The relative Conclusion: Q-actin™ demonstrated potential benefits in a healthy middle-aged and older adult population by improving sleep quality, as evidenced by elevated melatonin derivatives identified in urine samples and self-reported improvements on the Pittsburgh Sleep Quality Index and improved finger dexterity. These findings support the hypothesis that Q-actin™ may have positive effects on overall wellbeing, as shown here in healthy older people, and could be rated to enhanced sleep quality. Clinical trial registration: ISRCTN registry ISRCTN28705061 and clinicaltrials.gov/ NCT05878847.