SynthesisFrontiers in nutrition2025
Propolis supplementation on inflammatory and oxidative stress biomarkers in adults: a systematic review and meta-analysis of randomized controlled trials.
Synthesis in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Propolis effects on blood sugar and lipid metabolism, inflammatory indicators, and oxidative stress in people with type 2 diabetes: a systematic review and meta-analysis.Frontiers in nutrition · 2025Pooled it
- Propolis: A Natural Bioactive Compound with Emerging Roles in Functional Food Applications.International journal of molecular sciences · 2026Review
- Propolis in Obesity and Related Metabolic Disorders: Mechanistic and Clinical Insights-A Scoping Review.Nutrients · 2026Article
- Effects of propolis supplementation on blood glucose and lipid profiles in individuals with metabolic syndrome and type 2 diabetes: a systematic review and meta-analysis.Clinical nutrition research · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Although a large number of trials have observed the anti-inflammatory properties of propolis, the currently available research remains controversial regarding its beneficial health effects. Hence, the purpose of this study was to examine the effect of propolis on inflammatory and oxidative stress markers in adults. Methods: A comprehensive search was performed in Scopus, Web of Science, and PubMed/Medline to find relevant randomized controlled trials (RCTs) until January 2024. The overall effect sizes were calculated using the random-effects model and expressed as weighted mean differences (WMD) with a 95% confidence interval (CI). The possible heterogeneity between included trials was assessed by performing Cochran's Q test. Results: In total, 27 trials with 29 treatment arms were eligible for inclusion in this review. This meta-analysis revealed that propolis consumption led to a significant decrease in C-reactive protein (CRP) (WMD: -1.23; 95%CI: -1.76, -0.69; Conclusion: Propolis supplementation appears effective in reducing inflammation and oxidative stress by enhancing antioxidant capacity and reducing specific inflammatory markers. However, variations in study designs, dosages, and participant characteristics contribute to the heterogeneity of results. Further well-designed RCTs are needed to confirm these findings and determine the optimal dosage and long-term effects. Given its potential anti-inflammatory and antioxidant properties, propolis may serve as a complementary approach in managing inflammation-related conditions, though its clinical application requires further validation. Systematic review registration: https://clinicaltrials.gov/, identifier CRD42023474033.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.