Evidence map›Paper›PMID 40422003›Full record

ArticleInfection and immunity2025

Differentiating

Christopher C Wells, Tanja Petnicki-Ocwieja, Shumin Tan, Stephen C Bunnell, Sam R Telford, Linden T Hu, Jeffrey S Bourgeois

Abstract read
In one paragraph

Article in Infection and immunity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Christopher C WellsDepartment of Immunology, Tufts University, Boston, Massachusetts, USA.ORCID 0000-0003-2260-8546
Tanja Petnicki-OcwiejaTufts Lyme Disease Initiative, Tufts University, Boston, Massachusetts, USA.
Shumin TanDepartment of Molecular Biology and Microbiology, Tufts University, Boston, Massachusetts, USA.ORCID 0000-0003-1093-2576
Stephen C BunnellDepartment of Immunology, Tufts University, Boston, Massachusetts, USA.
Sam R TelfordTufts Lyme Disease Initiative, Tufts University, Boston, Massachusetts, USA.ORCID 0000-0003-4548-8663
Linden T HuTufts Lyme Disease Initiative, Tufts University, Boston, Massachusetts, USA.ORCID 0000-0003-1659-5558
Jeffrey S BourgeoisTufts Lyme Disease Initiative, Tufts University, Boston, Massachusetts, USA.ORCID 0000-0001-9037-8418

Funding

Heritable immunization of the white-footed mouse reservoir of Lyme diseaseR01AI152209 · NIAID · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ESVELT, KEVIN, JAENISCH, RUDOLF · 2021 to 2025
$4.7M
Development and Field Testing of a Novel Reservoir Targeted Antibiotic Against Borrelia burgdorferiR01AI152210 · NIAID · TUFTS UNIVERSITY BOSTON · PI HU, LINDEN T, LEWIS, KIM · 2020 to 2025
$3.9M
Role of human innate immune mutations in loss of tolerance to Borrelia burgdorferiR01AI150157 · NIAID · TUFTS UNIVERSITY BOSTON · PI HU, LINDEN T · 2020 to 2024
$3.0M
Identifying Determinants of Borrelia burgdorferi and Peromyscus leucopus symbiosisF32AI179104 · NIAID · TUFTS UNIVERSITY BOSTON · PI BOURGEOIS, JEFFREY · 2023 to 2025
$143k
Global Lyme AllianceNational Institute of Allergy and Infectious Diseases F32AI179104National Institute of Allergy and Infectious Diseases R01AI150157National Institute of Allergy and Infectious Diseases R01AI152209National Institute of Allergy and Infectious Diseases R01AI152210NIAID NIH HHS F32 AI179104NIAID NIH HHS R01 AI150157NIAID NIH HHS R01 AI152209NIAID NIH HHS R01 AI152210
6 · The paper itself

Abstract

Currently, most tools utilized in host-pathogen interaction studies depend on the use of human or mouse (

Indexed as

Bone Marrow CellsBorrelia burgdorferiCell DifferentiationLipopolysaccharidesLyme DiseaseMacrophagesPeromyscusAnimalsHEK293 CellsHost-Pathogen InteractionsHumansMiceMice, Inbred C57BLLipopolysaccharidesBorrelia burgdorferiBorreliella burgdorferiimmune responselipopolysaccharideLPSLyme diseasemacrophagePeromyscus leucopusreservoir

Identifiers

PMID40422003
PMCPMC12234436

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.