Evidence map›Paper›PMID 40422212›Full record

ArticleCells2025

A Potential Role for c-MYC in the Regulation of Meibocyte Cell Stress.

Isabella Boyack, Autumn Berlied, Cornelia Peterson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Isabella BoyackDepartment of Comparative Pathobiology, Tufts University, North Grafton, MA 01536, USA.
Autumn BerliedDepartment of Comparative Pathobiology, Tufts University, North Grafton, MA 01536, USA.
Cornelia PetersonDepartment of Comparative Pathobiology, Tufts University, North Grafton, MA 01536, USA.ORCID 0000-0001-6550-1883

Funding

Cross-Disciplinary Research Training for Veterinary StudentsT35OD033655 · OD · TUFTS UNIVERSITY BOSTON · PI Cheryl A London, Kelly Ann Metcalf Pate · 2022 to 2026
$459k
Investigating the Role of MYC in Meibomian Gland OncogenesisK01OD034451 · OD · TUFTS UNIVERSITY BOSTON · PI Cornelia Ward Mary Peterson · 2024 to 2026
$380k
NIH HHS K01 OD034451NIH HHS K01OD034451-01 (CP); T35OD033655 (IB; PI: London)NIH HHS T35 OD033655
6 · The paper itself

Abstract

The integrated stress response (ISR) is a key regulator of cell survival, promoting apoptosis through the effector protein CHOP in instances of prolonged or severe stress. The ISR's role in the initiation and progression of epithelial malignancies has been investigated; however, the ISR has not been evaluated in ocular adnexal sebaceous carcinoma (SebCA). Though uncommon, mortality rates of up to 40% have been reported, and the mechanisms underlying SebCA tumorigenesis remain unresolved; however,

Indexed as

Epithelial CellsMeibomian GlandsProto-Oncogene Proteins c-mycStress, PhysiologicalAnimalsApoptosisCell ProliferationHumansMiceTamoxifenTranscription Factor CHOPafimoxifeneProto-Oncogene Proteins c-mycTamoxifenTranscription Factor CHOPapoptosisCHOPfatty acid synthaseintegrated stress responselipogenesisMeibomian gland epithelial cellsMYCsebaceous carcinoma

Identifiers

PMID40422212
PMCPMC12109776

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.