Evidence map›Paper›PMID 40422222›Full record

ArticleCells2025

Nerve Growth Factor Modulates Regulatory Cell Volume Behavior via Stimulating TRPV1, TRPM8 Channels and Inducing Ca

Friedrich Wolf, Tina Dietrich-Ntoukas, Peter S Reinach, Uwe Pleyer, Stefan Mergler

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Friedrich WolfDepartment of Ophthalmology, Charité-Universitätsmedizin Berlin, Campus Virchow-Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany.ORCID 0009-0004-6322-8034
Tina Dietrich-NtoukasDepartment of Ophthalmology, Charité-Universitätsmedizin Berlin, Campus Virchow-Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany.ORCID 0000-0002-9041-2249
Peter S ReinachSchool of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou 325015, China.ORCID 0000-0002-3494-4523
Uwe PleyerDepartment of Ophthalmology, Charité-Universitätsmedizin Berlin, Campus Virchow-Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany.ORCID 0000-0002-5569-1473
Stefan MerglerDepartment of Ophthalmology, Charité-Universitätsmedizin Berlin, Campus Virchow-Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany.ORCID 0000-0001-8608-648X

Funding

Berliner Sonnenfeld-Stiftung not provided
6 · The paper itself

Abstract

NGF plays important roles in ocular surface homeostasis and different pathological conditions. One effect includes promoting conjunctival epithelial cell differentiation and mucin secretion. This study characterizes the individual roles of TRPV1 and TRPM8 channel activity in mediating the effects of NGF on intracellular Ca

Indexed as

Calcium SignalingConjunctivaEpithelial CellsNerve Growth FactorTRPM Cation ChannelsTRPV Cation ChannelsCalciumCell LineCell SizeHumansCalciumNerve Growth FactorTRPM8 protein, humanTRPM Cation ChannelsTRPV1 protein, humanTRPV Cation ChannelsCa2+ regulationconjunctival epithelial cellsnerve growth factorTRPM 8TRPV 1

Identifiers

PMID40422222
PMCPMC12109909

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.