Evidence map›Paper›PMID 40422241›Full record

ReviewCells2025

Neutrophils at the Crossroads of Inflammatory Bowel Disease and Atherosclerosis: A State-of-the-Art Review.

Vadim Genkel, Yana Zaripova, Alla Kuznetsova, Alena Sluchanko, Anna Minasova, Maria Zotova, Anna Saenko, Albina Savochkina, Anastasiya Dolgushina

Abstract readReview
In one paragraph

Review in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Vadim GenkelDepartment of Internal Medicine, South-Ural State Medical University, Chelyabinsk 454141, Russia.ORCID 0000-0001-5902-3803
Yana ZaripovaDepartment of Internal Medicine, South-Ural State Medical University, Chelyabinsk 454141, Russia.ORCID 0000-0002-7039-838X
Alla KuznetsovaDepartment of Hospital Therapy, South-Ural State Medical University, Chelyabinsk 454141, Russia.
Alena SluchankoDepartment of Hospital Therapy, South-Ural State Medical University, Chelyabinsk 454141, Russia.ORCID 0000-0003-3323-9854
Anna MinasovaResearch Institution of Immunology, South-Ural State Medical University, Chelyabinsk 454141, Russia.
Maria ZotovaResearch Institution of Immunology, South-Ural State Medical University, Chelyabinsk 454141, Russia.
Anna SaenkoDepartment of Hospital Therapy, South-Ural State Medical University, Chelyabinsk 454141, Russia.ORCID 0000-0002-3481-8092
Albina SavochkinaResearch Institution of Immunology, South-Ural State Medical University, Chelyabinsk 454141, Russia.
Anastasiya DolgushinaDepartment of Hospital Therapy, South-Ural State Medical University, Chelyabinsk 454141, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammatory bowel disease (IBD) is a growing global problem, particularly in regions with low sociodemographic indices and growing populations. IBD incidence is increasing among children and adolescents, leading to a growing economic burden. The prevalence of atherosclerotic cardiovascular diseases among patients with IBD is also higher than in the general population. While mortality rates have decreased, cardiovascular disease (CVD) remains a significant contributor to mortality and disability in IBD patients. According to the current understanding, neutrophils play an important role in both the atherogenesis and pathogenesis of IBD. This review addresses the state of the art of neutrophil involvement in the development of atherosclerosis and IBD. In the present review, we summarize the currently available evidence regarding neutrophils as a possible key driver of extraintestinal manifestations of IBD and cardiovascular complications. We provide a discussion on the potential role of neutrophil-derived markers in the development of new approaches for the precise diagnosis of atherosclerosis in patients with IBD, as well as new therapeutic targets.

Indexed as

AtherosclerosisInflammatory Bowel DiseasesNeutrophilsAnimalsBiomarkersHumansBiomarkersatherosclerosiscardiovascular diseaseCrohn’s diseaseinflammationinflammatory bowel diseaseneutrophilsulcerative colitis

Identifiers

PMID40422241
PMCPMC12110165

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.