Evidence map›Paper›PMID 40422666›Full record

ReviewJournal of fungi (Basel, Switzerland)2025

Gut Mycobiome: Latest Findings and Current Knowledge Regarding Its Significance in Human Health and Disease.

Bogdan Severus Gaspar, Oana Alexandra Roşu, Robert-Mihai Enache, Monica Manciulea Profir, Luciana Alexandra Pavelescu, Sanda Maria Creţoiu

Abstract readReview
In one paragraph

Review in Journal of fungi (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Bogdan Severus GasparDepartment of Surgery, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.ORCID 0000-0002-0056-0740
Oana Alexandra RoşuDepartment of Morphological Sciences, Cell and Molecular Biology and Histology, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Robert-Mihai EnacheDepartment of Radiology and Medical Imaging, Fundeni Clinical Institute, 022328 Bucharest, Romania.ORCID 0009-0003-9720-8704
Monica Manciulea ProfirDepartment of Morphological Sciences, Cell and Molecular Biology and Histology, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.ORCID 0009-0006-7596-7330
Luciana Alexandra PavelescuDepartment of Morphological Sciences, Cell and Molecular Biology and Histology, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Sanda Maria CreţoiuDepartment of Morphological Sciences, Cell and Molecular Biology and Histology, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.ORCID 0000-0003-2575-4880

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The gut mycobiome, the fungal component of the gut microbiota, plays a crucial role in health and disease. Although fungi represent a small fraction of the gut ecosystem, they influence immune responses, gut homeostasis, and disease progression. The mycobiome's composition varies with age, diet, and host factors, and its imbalance has been linked to conditions such as inflammatory bowel disease (IBD) and metabolic disorders. Advances in sequencing have expanded our understanding of gut fungi, but challenges remain due to methodological limitations and high variability between individuals. Emerging therapeutic strategies, including antifungals, probiotics, fecal microbiota transplantation, and dietary interventions, show promise but require further study. This review highlights recent discoveries on the gut mycobiome, its interactions with bacteria, its role in disease, and potential clinical applications. A deeper understanding of fungal contributions to gut health will help develop targeted microbiome-based therapies.

Indexed as

dysbiosisfungigut microbiotagut mycobiome

Identifiers

PMID40422666
PMCPMC12112676

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.