Evidence map›Paper›PMID 40422839›Full record

ArticleJournal of functional biomaterials2025

Wharton's Jelly Bioscaffolds Improve Cardiac Repair with Bone Marrow Mononuclear Stem Cells in Rats.

Luize Kremer Gamba, Laiza Kremer Gamba, Camila da Costa, Aline Luri Takejima, Rossana Baggio Simeoni, Isabella Cristina Mendes Rossa, Anna Clara Faidiga Silva, Julia Letícia de Bortolo, Marcos Antônio Denk, Seigo Nagashima and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of functional biomaterials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Luize Kremer GambaExperimental Laboratory of Institute of Biological and Health Sciences, Pontifícia Universidade Católica do Paraná (PUCPR), Curitiba 80215-901, PR, Brazil.ORCID 0000-0003-4415-6210
Laiza Kremer GambaGraduate Program in Health Sciences, Centro Universitário para o Desenvolvimento do Alto Vale do Itajaí, Rio do Sul 89160-932, SC, Brazil.
Camila da CostaLaboratory of Experimental Pathophysiology, Graduate Program in Health Sciences, Universidade do Extremo Sul Catarinense, Criciúma 88806-000, SC, Brazil.
Aline Luri TakejimaExperimental Laboratory of Institute of Biological and Health Sciences, Pontifícia Universidade Católica do Paraná (PUCPR), Curitiba 80215-901, PR, Brazil.ORCID 0000-0002-2608-0171
Rossana Baggio SimeoniExperimental Laboratory of Institute of Biological and Health Sciences, Pontifícia Universidade Católica do Paraná (PUCPR), Curitiba 80215-901, PR, Brazil.
Isabella Cristina Mendes RossaExperimental Laboratory of Institute of Biological and Health Sciences, Pontifícia Universidade Católica do Paraná (PUCPR), Curitiba 80215-901, PR, Brazil.
Anna Clara Faidiga SilvaExperimental Laboratory of Institute of Biological and Health Sciences, Pontifícia Universidade Católica do Paraná (PUCPR), Curitiba 80215-901, PR, Brazil.
Julia Letícia de BortoloExperimental Laboratory of Institute of Biological and Health Sciences, Pontifícia Universidade Católica do Paraná (PUCPR), Curitiba 80215-901, PR, Brazil.
Marcos Antônio DenkExperimental Laboratory of Institute of Biological and Health Sciences, Pontifícia Universidade Católica do Paraná (PUCPR), Curitiba 80215-901, PR, Brazil.
Seigo NagashimaExperimental Laboratory of Institute of Biological and Health Sciences, Pontifícia Universidade Católica do Paraná (PUCPR), Curitiba 80215-901, PR, Brazil.
Carlos de Almeida BarbosaGraduate Program in Pharmacy, Centro Universitário Curitiba-Unicuritiba, Curitiba 80220-181, PR, Brazil.
Paulo Cesar Lock SilveiraLaboratory of Experimental Pathophysiology, Graduate Program in Health Sciences, Universidade do Extremo Sul Catarinense, Criciúma 88806-000, SC, Brazil.ORCID 0000-0003-4908-2257
Júlio César FranciscoExperimental Laboratory of Institute of Biological and Health Sciences, Pontifícia Universidade Católica do Paraná (PUCPR), Curitiba 80215-901, PR, Brazil.
Luiz César Guarita-SouzaExperimental Laboratory of Institute of Biological and Health Sciences, Pontifícia Universidade Católica do Paraná (PUCPR), Curitiba 80215-901, PR, Brazil.ORCID 0000-0003-2781-9705

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study assessed the impact of implanting mononuclear stem cells and Wharton's Jelly (WJ), either separately or together, on left ventricular dysfunction following myocardial infarction in Wistar rats. Functional and histopathological parameters were analyzed, and a rat model of left anterior descending coronary artery ligation was used. Treatments included an intramyocardial injection of 0.9% sodium chloride (control,

Indexed as

bioscaffoldsbone marrow mononuclear stem cellscardiac repairmyocardial infarctionratsregenerative medicinetissue engineeringWharton’s Jelly

Identifiers

PMID40422839
PMCPMC12112017

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.