Evidence map›Paper›PMID 40422845›Full record

ArticleJournal of functional biomaterials2025

In Vivo Cell Migration and Growth Within Electrospun Porous Nanofibrous Scaffolds with Different Pore Sizes in a Mouse Pouch Model.

David C Markel, Therese Bou-Akl, Bin Wu, Pawla Pawlitz, Xiaowei Yu, Liang Chen, Tong Shi, Weiping Ren

Abstract read
In one paragraph

Article in Journal of functional biomaterials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Electrospun Fibers EncapsulatingMolecules (Basel, Switzerland) · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

David C MarkelDepartment of Orthopedics, Henry Ford Providence Southfield Hospital, Southfield, MI 48075, USA.ORCID 0000-0001-6405-1454
Therese Bou-AklDepartment of Orthopedics, Henry Ford Providence Southfield Hospital, Southfield, MI 48075, USA.ORCID 0000-0001-5885-906X
Bin WuDepartment of Orthopedics, Henry Ford Providence Southfield Hospital, Southfield, MI 48075, USA.
Pawla PawlitzDepartment of Orthopedics, Henry Ford Providence Southfield Hospital, Southfield, MI 48075, USA.
Xiaowei YuDepartment of Orthopedics, 6th People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200233, China.
Liang ChenDepartment of Biomedical Engineering, Wayne State University, Detroit, MI 48201, USA.
Tong ShiDepartment of Biomedical Engineering, Wayne State University, Detroit, MI 48201, USA.
Weiping RenDepartment of Orthopedics, Henry Ford Providence Southfield Hospital, Southfield, MI 48075, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cellular infiltration into traditional electrospun nanofibers (NFs) is limited due to their dense structures. We were able to obtain polycaprolactone (PCL) NFs with variable and defined pore sizes and thicknesses by using a customized programmed NF collector that controls the moving speed during electrospinning. NFs obtained by this method were tested in vitro and have shown better cell proliferation within the NFs with larger pore sizes. This study investigated in vivo host cell migration and neovascularization within implanted porous PCL NF discs using a mouse pouch model. Four types of PCL NFs were prepared and classified based on the electrospinning speed: NF-zero (static control), NF-low (0.085 mm/min), NF-mid (0.158 mm/min) and NF-high (0.232 mm/min) groups. With the increase in the speed, we observed an increase in the pore area; NF-zero (11.6 ± 6.2 μm

Indexed as

electrospinningmicrostructuresmouse pouch modelporous nanofiberregenerative medicinetissue growth

Identifiers

PMID40422845
PMCPMC12112096

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.