Evidence map›Paper›PMID 40422874›Full record

ArticleMetabolites2025

Circulating Amino Acid Changes Three Years After Bariatric Surgery.

Ina Maltais-Payette, Fannie Lajeunesse-Trempe, Mélanie Nadeau, Léonie Bouvet-Bouchard, Frédéric Simon Hould, Laurent Biertho, André Tchernof

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In one paragraph

Article in Metabolites, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ina Maltais-PayetteHeart and Lung Institute, Laval University, Quebec, QC G1V 4G5, Canada.
Fannie Lajeunesse-TrempeHeart and Lung Institute, Laval University, Quebec, QC G1V 4G5, Canada.ORCID 0009-0002-4036-7854
Mélanie NadeauHeart and Lung Institute, Laval University, Quebec, QC G1V 4G5, Canada.
Léonie Bouvet-BouchardHeart and Lung Institute, Laval University, Quebec, QC G1V 4G5, Canada.
Frédéric Simon HouldHeart and Lung Institute, Laval University, Quebec, QC G1V 4G5, Canada.
Laurent BierthoHeart and Lung Institute, Laval University, Quebec, QC G1V 4G5, Canada.
André TchernofHeart and Lung Institute, Laval University, Quebec, QC G1V 4G5, Canada.ORCID 0000-0002-2587-1000

Funding

Canadian Institutes of Health Research (CIHR) TB2-138776Johnson & Johnson Medical Companies ETH-14-610
6 · The paper itself

Abstract

BACKGROUND AND

objectiveStudies using metabolomics to study bariatric surgery have shown that amino acids are one of the most changed groups of metabolites after the intervention. However, the surgery-related variation in individual amino acids, as well as the long-term impact and the differences between the types of surgeries, have been poorly studied. The aim of this study was to investigate the changes in circulating amino acids after three types of bariatric surgery up to 36 months after the intervention.

methodsWe studied 63 participants diagnosed with T2D at baseline, who received either a sleeve gastrectomy, a Roux-en-Y gastric bypass or a biliopancreatic diversion with duodenal switch. We measured the concentrations of 16 circulating amino acids in fasting plasma before the surgery as well as after 4, 12, 24 and 36 months via liquid chromatography coupled with mass spectrometry (LC-MS/MS).

resultsEleven circulating amino acids were significantly modified by bariatric surgery. Glutamate, leucine and isoleucine showed the greatest decrease. Most of the changes in circulating amino acids occurred within 1 year of the operations. Only one measured plasmatic amino acid (threonine) had a significantly different change pattern according to surgery types. In repeated-measure correlations, changes in circulating amino acids were significantly associated with changes in adiposity and metabolic markers.

conclusionsBariatric surgery changes the levels of most circulating amino acids, and the effect occurs in the short term without major differences between surgery types. The mechanisms explaining these changes are not elucidated but likely include modifications in amino acid metabolism.

Indexed as

amino acidsbariatric surgeryobesity

Identifiers

PMID40422874
PMCPMC12112989

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.