Evidence map›Paper›PMID 40422899›Full record

ArticleMetabolites2025

Plasma Metabolic Outliers Identified in Estonian Human Knockouts.

Ketian Yu, Estonian Biobank Research Team, Karol Estrada, Tõnu Esko, Mart Kals, Tiit Nikopensius, Jaanika Kronberg, Urmo Võsa, Arthur Wuster, Lorenzo Bomba

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolites, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ketian YuGenomics, BioMarin Pharmaceutical, Novato, CA 94949, USA.ORCID 0000-0001-9994-3399
Estonian Biobank Research Team
Karol EstradaGenomics, BioMarin Pharmaceutical, Novato, CA 94949, USA.
Tõnu EskoEstonian Genome Centre, Institute of Genomics, University of Tartu, 51010 Tartu, Estonia.
Mart KalsEstonian Genome Centre, Institute of Genomics, University of Tartu, 51010 Tartu, Estonia.ORCID 0000-0003-2090-8780
Tiit NikopensiusEstonian Genome Centre, Institute of Genomics, University of Tartu, 51010 Tartu, Estonia.ORCID 0000-0002-0816-7804
Jaanika KronbergEstonian Genome Centre, Institute of Genomics, University of Tartu, 51010 Tartu, Estonia.ORCID 0000-0003-2362-656X
Urmo VõsaEstonian Genome Centre, Institute of Genomics, University of Tartu, 51010 Tartu, Estonia.
Arthur WusterGenomics, BioMarin Pharmaceutical, Novato, CA 94949, USA.
Lorenzo BombaGenomics, BioMarin Pharmaceutical, Novato, CA 94949, USA.ORCID 0000-0002-6290-8984

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

drug developmenthuman knockoutsmetabolomicspharmacogenomicspredicted loss of functionpyrimidine pathway

Identifiers

PMID40422899
PMCPMC12114030

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.