Evidence mapPaperPMID 40422965Full record

ReviewJournal of cardiovascular development and disease2025

Drug-Coated Balloons: Recent Evidence and Upcoming Novelties.

Zaid Mohammad Fahmi Shahrori, Marco Frazzetto, Shamin Hayat Mahmud, Wasfi Alghwyeen, Bernardo Cortese

Abstract readReview
In one paragraph

Review in Journal of cardiovascular development and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Observational
  5. Review
  6. Drug-coated balloons and diabetes: a review.Cardiovascular diabetology · 2025
    Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zaid Mohammad Fahmi ShahroriHarrington Heart & Vascular Institute, University Hospitals Cleveland, Cleveland, OH 44106, USA.ORCID 0000-0001-7705-2595
Marco FrazzettoHarrington Heart & Vascular Institute, University Hospitals Cleveland, Cleveland, OH 44106, USA.ORCID 0000-0002-6543-7567
Shamin Hayat MahmudHarrington Heart & Vascular Institute, University Hospitals Cleveland, Cleveland, OH 44106, USA.ORCID 0000-0001-7628-7333
Wasfi AlghwyeenAl-Nadeem Hospital, Ministry of Health, Amman 11118, Jordan.ORCID 0000-0002-3060-0854
Bernardo CorteseHarrington Heart & Vascular Institute, University Hospitals Cleveland, Cleveland, OH 44106, USA.ORCID 0000-0002-5808-7810

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Drug-coated balloons (DCBs) have emerged as a compelling alternative to drug-eluting stents in the treatment of coronary artery disease (CAD), offering the advantage of local drug delivery without permanent vascular scaffold implantation. Initially developed for managing in-stent restenosis, DCBs seem appealing for broader indications, particularly in small vessel disease and bifurcation lesions. While paclitaxel-based DCBs remain the most investigated, newer limus formulations are showing promise and appear to be a valid alternative in early trials. Evidence from recent randomized clinical trials (RCTs) and meta-analyses highlights DCBs as a safe and effective option in selected patients, with potential benefits including lower restenosis rates, reduced need for dual antiplatelet therapy, and avoidance of late stent-related complications. As new large-scale trials near completion, DCBs are poised to take on a broader role in the treatment of CAD, particularly in patients where "leaving nothing behind" offers a clinical advantage. This review offers an overview of the DCB platforms commercially available, showing pharmacological differences, providing current indications in practical guidelines, and analyzing the most recent and impactful RCTs and meta-analyses in the field.

Indexed as

coronary artery diseaseDCBdrug-coated balloonsPCI

Identifiers

PMID40422965
PMCPMC12112549

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.