ArticleThe Journal of organic chemistry2025
Protective Group-Dependent Iridium-Catalyzed CH Borylations of Levodopa.
Article in The Journal of organic chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Despite being an important aromatic amino acid, iridium-catalyzed borylation (CHB) of levodopa has not been reported. Via the application of carefully chosen protecting groups for the catechol moiety, the steric hindrance around the arene can be reduced, enabling selective C5 CHB of levodopa. Methylene and boronic ester protecting groups were explored, the latter of which is deprotected in situ to yield the free catechol.
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