Evidence map›Paper›PMID 40423481›Full record

ArticleToxics2025

Pulmonary Toxicity of Long, Thick MWCNT and Very Long, Thin Carboxylated MWCNT Aerosols Following 28 Days Whole-Body Exposure.

Chang Guo, Matthew D Wright, Alison Buckley, Adam Laycock, Trine Berthing, Ulla Vogel, Frédéric Cosnier, Laurent Gaté, Martin O Leonard, Rachel Smith

Abstract read
In one paragraph

Article in Toxics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chang GuoToxicology Department, UK Health Security Agency, Harwell Campus, Didcot OX11 0RQ, UK.ORCID 0000-0002-9662-1885
Matthew D WrightToxicology Department, UK Health Security Agency, Harwell Campus, Didcot OX11 0RQ, UK.
Alison BuckleyToxicology Department, UK Health Security Agency, Harwell Campus, Didcot OX11 0RQ, UK.ORCID 0000-0001-5029-4121
Adam LaycockToxicology Department, UK Health Security Agency, Harwell Campus, Didcot OX11 0RQ, UK.ORCID 0000-0001-9480-5149
Trine BerthingNational Research Centre for the Working Environment, DK-2100 Copenhagen, Denmark.ORCID 0000-0003-0723-9869
Ulla VogelNational Research Centre for the Working Environment, DK-2100 Copenhagen, Denmark.ORCID 0000-0001-6807-1524
Frédéric CosnierFrench Research and Safety Institute for the Prevention of Occupational Accidents and Diseases (INRS), Toxicology and Biomonitoring Division, 54519 Vandoeuvre les Nancy, France.ORCID 0000-0002-8596-927X
Laurent GatéFrench Research and Safety Institute for the Prevention of Occupational Accidents and Diseases (INRS), Toxicology and Biomonitoring Division, 54519 Vandoeuvre les Nancy, France.ORCID 0000-0001-5629-7390
Martin O LeonardToxicology Department, UK Health Security Agency, Harwell Campus, Didcot OX11 0RQ, UK.
Rachel SmithToxicology Department, UK Health Security Agency, Harwell Campus, Didcot OX11 0RQ, UK.ORCID 0000-0002-9784-3586

Funding

European Union 7th Framework Programme, Project NANoREG, Grant agreement no. 310584.
6 · The paper itself

Abstract

Pulmonary exposure to carbon nanotubes (CNTs) has been linked to a series of adverse respiratory effects in animal models, including inflammation, genotoxicity, fibrosis, and granuloma formation, the degree and characteristics of which are considered dependent upon the detailed physicochemical properties of the material as inhaled. To further explore the effect of variations in physicochemical properties on pulmonary effects, two different multi-walled CNTs (MWCNTs) were tested in vivo: a pristine MWCNT (pMWCNT) (NM-401) and a surface-modified MWCNT (MWCNT-COOH). Female Sprague-Dawley rats were whole-body exposed for 28 days to MWCNT aerosols (pMWCNT (0.5 and 1.5 mg/m

Indexed as

carbon nanotubesCNTinhalationMWCNTnanotoxicologyNM-401osteopontinratwhole-body

Identifiers

PMID40423481
PMCPMC12115612

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.