Evidence map›Paper›PMID 40423494›Full record

ArticleToxics2025

Effects of Lead Exposure on 1573 Male Workers' Sex Hormones in China.

Ping Wang, Zhiling Wu, Ju Li, Yue Li, Xuefeng Wang, Mengya Ma, Wenkai Wei, Yijun Wang, Yi Liu, Yi Sun and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Ping WangDepartment of Labor Health, School of Public Health, Shanxi Medical University, Taiyuan 030001, China.ORCID 0009-0009-2074-8853
Zhiling WuDepartment of Environmental Health, College of Preventive Medicine, Third Military Medical University (Army Medical University), Chongqing 400038, China.
Ju LiSchool of Inspection, Xinyang Vocational and Technical College, Xinyang 464000, China.
Yue LiHenan International Collaborative Laboratory for Health Effects and Intervention of Air Pollution, School of Public Health, Xinxiang Medical University, Xinxiang 453003, China.
Xuefeng WangHenan International Collaborative Laboratory for Health Effects and Intervention of Air Pollution, School of Public Health, Xinxiang Medical University, Xinxiang 453003, China.
Mengya MaHenan International Collaborative Laboratory for Health Effects and Intervention of Air Pollution, School of Public Health, Xinxiang Medical University, Xinxiang 453003, China.
Wenkai WeiHenan International Collaborative Laboratory for Health Effects and Intervention of Air Pollution, School of Public Health, Xinxiang Medical University, Xinxiang 453003, China.
Yijun WangHenan International Collaborative Laboratory for Health Effects and Intervention of Air Pollution, School of Public Health, Xinxiang Medical University, Xinxiang 453003, China.
Yi LiuHenan International Collaborative Laboratory for Health Effects and Intervention of Air Pollution, School of Public Health, Xinxiang Medical University, Xinxiang 453003, China.
Yi SunHenan International Collaborative Laboratory for Health Effects and Intervention of Air Pollution, School of Public Health, Xinxiang Medical University, Xinxiang 453003, China.
Ling TaoSchool of Inspection, Xinyang Vocational and Technical College, Xinyang 464000, China.
Yanyan YangXinyang Center for Disease Control and Prevention, Xinyang 453003, China.
Ziyuan ZhouDepartment of Environmental Health, College of Preventive Medicine, Third Military Medical University (Army Medical University), Chongqing 400038, China.ORCID 0000-0002-7689-9601
Jingchao RenSchool of Public Health, Chongqing Medical University, Chongqing 400038, China.
Jia CaoKey Lab of Medical Protection for Electromagnetic Radiation, Ministry of Education of China, Institute of Toxicology, College of Preventive Medicine, Third Military Medical University (Army Medical University), Chongqing 400038, China.
Guanghui ZhangDepartment of Environmental Health, College of Preventive Medicine, Third Military Medical University (Army Medical University), Chongqing 400038, China.

Funding

2024 University-level Research Fund Project of Xinyang Vocational and Technical College No. LXZD241101National Natural Science Foundation of China Grant No. 82273663
6 · The paper itself

Abstract

Lead (Pb) is recognized as an environmental pollutant with male reproductive toxicity, but its effects on sex hormones remain unclear. This study investigated the relationship between male blood lead levels (BLLs) and the sex hormones of luteinizing hormone (LH), follicle-stimulating hormone (FSH), and prolactin (PRL), as well as testosterone (T), estrogen (E2), and progesterone (PROG). Observational and experimental data from 1573 Pb-exposed workers (712 had also been surveyed in the previous year) and 35 Pb-poisoned patients (before and after Pb chelation therapy) were analyzed. Results from a cross-sectional study showed a nonlinear relationship between BLLs and LH/FSH, and a linear relationship between BLLs and serum T. After Pb chelation therapy, the BLLs in patients decreased from 61.7 to 36.3 (μg/dL), serum T and FSH decreased significantly (

Indexed as

blood lead levelsluteinizing hormonemediating effectssex hormonestestosterone

Identifiers

PMID40423494
PMCPMC12115724

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.