Evidence map›Paper›PMID 40423733›Full record

ArticleActa diabetologica2025

Predictive factors of major amputation in patients with diabetic foot ulcers treated by peripheral blood mononuclear cells.

Marco Meloni, Ermanno Bellizzi, Luigi Uccioli, Laura Giurato, Valeria Ruotolo, Martina Salvi, Federico Rolando Bonanni, Aikaterini Andreadi, Alfonso Bellia, Davide Lauro

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In one paragraph

Article in Acta diabetologica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Observational
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Marco Meloni *Department of Systems of Medicine, University of Tor Vergata, Viale Oxford 81, Rome, 00133, Italy. meloni.marco@libero.it.ORCID http://orcid.org/0000-0003-3789-9622
Ermanno Bellizzi *Department of Systems of Medicine, University of Tor Vergata, Viale Oxford 81, Rome, 00133, Italy.
Luigi UccioliDepartment of Endocrinology and Diabetology, CTO Hospital, Rome, 00145, Italy.
Laura GiuratoDepartment of Endocrinology and Diabetology, CTO Hospital, Rome, 00145, Italy.
Valeria RuotoloDivision of Endocrinology and Diabetology, Department of Medical Sciences, University Hospital Fondazione Policlinico Tor Vergata, Viale Oxford 81, Rome, 00133, Italy.
Martina SalviDepartment of Systems of Medicine, University of Tor Vergata, Viale Oxford 81, Rome, 00133, Italy.
Federico Rolando BonanniDepartment of Systems of Medicine, University of Tor Vergata, Viale Oxford 81, Rome, 00133, Italy.
Aikaterini AndreadiDepartment of Systems of Medicine, University of Tor Vergata, Viale Oxford 81, Rome, 00133, Italy.
Alfonso BelliaDepartment of Systems of Medicine, University of Tor Vergata, Viale Oxford 81, Rome, 00133, Italy.
Davide LauroDepartment of Systems of Medicine, University of Tor Vergata, Viale Oxford 81, Rome, 00133, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimPeripheral blood mononuclear cells (PB-MNCs) therapy is an adjuvant treatment for patients with ischaemic diabetic foot ulcers (DFUs) and no-option critical limb ischemia (NO-CLI). This study aimed to evaluate factors influencing the effectiveness of PB-MNC therapy.

methodThis prospective, not controlled study included a cohort of patients with DFUs and NO-CLI treated by PB-MNCs. NO-CLI was defined as the revascularization failure with desert foot (absence of any artery below-the-ankle) or partial desert foot (absence of a wound-related artery with TcPO RESULTS/DISCUSSION: Sixty-four patients were included. The mean age was 73.8 ± 5.8 years, 75% were male, and all of them had type 2 diabetes. At one year of follow-up, major amputation was documented in 12.5% of patients. Amputees had a higher rate of desert foot (vs. partial desert foot) (100% vs. 25%, p < 0.0001), higher post-procedural pain (5.7 ± 1.9 vs. 2.2 ± 1.3, p < 0.0001), lower TcPO

conclusionPB-MNCs therapy resulted less effective in patients with complete desert foot, persistence of paint after therapy, heel involvement in persons with multiple ulcers, and impaired walking.

Indexed as

Amputation, SurgicalDiabetic FootLeukocytes, MononuclearAgedAged, 80 and overDiabetes Mellitus, Type 2FemaleHumansMaleMiddle AgedProspective StudiesTreatment OutcomeAmputationDiabetesDiabetic footPeripheral arterial diseasePeripheral blood mononuclear cells

Identifiers

PMID40423733
PMCPMC12640342

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.