ArticleInflammation2025
The Biological Role of the Signal Transducer and Activator of Transcription 1 (STAT1)-miR-221/222-3p-p21 Activated Kinase 1 (PAK1) Axis in Experimental Periodontitis.
Article in Inflammation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- High uPAR and Low miR-221 Expression Predict Poor Disease-Free Survival in Triple-Negative Breast Cancer.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026Article
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7 authors.
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Abstract
Periodontitis is a chronic inflammatory disease characterized by the progressive destruction of tooth-supporting tissues. Despite extensive research, the molecular mechanisms underlying its pathogenesis remain incompletely understood. This study aimed to investigate the role and regulatory mechanisms of miR-221/222-3p in experimental periodontitis. The expression of miR-221/222-3p in lipopolysaccharide (LPS)-stimulated periodontal ligament cells (PDLCs) and ligation-induced rat periodontitis were detected by RT-qPCR. miR-221/222-3p agomir were administrated topically in ligation-induced rat periodontitis. The therapeutic function of both miRNAs were assessed by micro-CT, TRAP staining, and immunohistochemistry. The mechanisms of miR-221/222-3p function in periodontitis were determined by cell assays. miR-221-3p and miR-222-3p expression were both downregulated in LPS-stimulated PDLCs and ligation-induced periodontitis rat. In vitro, miR-221-3p and miR-222-3p could alleviate the inflammatory damage of PDLCs upon LPS stimulation. Mechanically, PAK1 is demonstrated as a target gene of miR-221/222-3p. Additionally, STAT1 signaling pathway is activated by LPS treatment and STAT1 could bind to the upstream region of the miR-221/222-3p promoter and repress their expression. In vivo, miR-221/222-3p agomir rescued the alveolar bone loss, alleviated the infiltration of osteoclasts and the expression of inflammatory cytokines of periodontitis rats. Our results revealed a novel STAT1-miR-221/222-3p-PAK1 axis in the initiation and progression of periodontitis. Specific targeting this signaling pathway may provide a new therapeutic avenue for periodontitis.
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