Evidence map›Paper›PMID 40423876›Full record

ArticleProbiotics and antimicrobial proteins2026

Immune-Enhancing Effects of Two Potential Probiotic Strains Latilactobacillus curvatus WiKim0169 and Pediococcus acidilactici WiKim0170 in a Cyclophosphamide-Induced Immunosuppression Rat Model.

Eun-Jung Park, You-Suk Lee, Eun-Min Jun, Byung Wook Lee, Sang Min Park, Hae-Jeung Lee

Abstract read
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In one paragraph

Article in Probiotics and antimicrobial proteins, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Differential regulatory effects ofFood chemistry. Molecular sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Eun-Jung Park *Department of Food and Nutrition, College of BioNano Technology, Gachon University, Seongnam, Gyeonggi-Do, 13120, Republic of Korea.ORCID http://orcid.org/0000-0002-2778-1834
You-Suk Lee *Department of Food and Nutrition, College of BioNano Technology, Gachon University, Seongnam, Gyeonggi-Do, 13120, Republic of Korea.
Eun-Min JunDepartment of Food and Nutrition, College of BioNano Technology, Gachon University, Seongnam, Gyeonggi-Do, 13120, Republic of Korea.
Byung Wook LeeMicrobiome R&D Center, Pharmsville Co., Ltd, Seoul, 07793, Republic of Korea.
Sang Min ParkMicrobiome R&D Center, Pharmsville Co., Ltd, Seoul, 07793, Republic of Korea.
Hae-Jeung LeeDepartment of Food and Nutrition, College of BioNano Technology, Gachon University, Seongnam, Gyeonggi-Do, 13120, Republic of Korea. skysea@gachon.ac.kr.ORCID http://orcid.org/0000-0001-8353-3619

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Emerging evidence suggests that probiotics are beneficial for immunity and play a crucial role in regulating gut microbiota. However, the immune-enhancing effects of specific bacterial species remain uncertain. This study investigated the effects of two potential probiotic strains, Latilactobacillus curvatus WiKim0169 (Wilac L004, W4) and Pediococcus acidilactici WiKim0170 (Wilac L002, W2) isolated from fermented cabbage, on immune enhancement and gut microbiota changes in a cyclophosphamide-induced immunosuppression rat model. The results revealed that W4 and W2 improved natural killer cell activity, serum nitrite, and immunoglobulin levels. They also increased cytokine levels and activated the nuclear factor-κB pathway, substantiating the underlying mechanism of the immune-enhancing effects. Additionally, both strains altered gut microbiota composition by increasing bacteria that are being studied for their potential association with immune function. Taken together, both strains improved immune-related biomarkers and the gut microbiota. These findings suggest W4 and W2 as promising probiotics with immune-enhancing properties.

Indexed as

Pediococcus acidilacticiProbioticsAnimalsCyclophosphamideCytokinesGastrointestinal MicrobiomeImmunosuppression TherapyMaleRatsRats, Sprague-DawleyCyclophosphamideCytokinesImmune-enhancing effectLatilactobacillus curvatusPediococcus acidilactici

Identifiers

PMID40423876

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.