Evidence map›Paper›PMID 40423886›Full record

SynthesisNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2025

Optimal dose and type of exercise improve the overall balance in adults with Parkinson's disease: a systematic review and Bayesian network meta-analysis.

Xianjin Fan, Yuan Yuan, Ying Bai, Chen Cheng, Junyu Wang, Tao Wang, Yong Yang, Ko-Chia Chen

Abstract readSystematic ReviewNetwork Meta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xianjin FanSchool of Physical Education and Sport, Chaohu University, No. 1 Xuefu Road, Chaohu Economic Development Zone, Hefei, 238000, Anhui Province, China.
Yuan YuanDepartment of Physical Education, Kunsan National University, Kunsan, 541150, Korea.
Ying BaiDepartment of Physical Education, Kunsan National University, Kunsan, 541150, Korea.
Chen ChengSchool of Tennis, Wuhan Sports University, Wuhan, 430079, China.
Junyu WangSchool of Exercise and Health, Shanghai University of Sport, Shanghai, 200438, China.
Tao WangCollege of Physical Education and Health, Southwest University of Science and Technology, Mianyang, 621010, China.
Yong YangSchool of Physical Education and Sport, Chaohu University, No. 1 Xuefu Road, Chaohu Economic Development Zone, Hefei, 238000, Anhui Province, China. yangyong@henu.edu.cn.ORCID http://orcid.org/0000-0001-8598-5379
Ko-Chia ChenDepartment of Sport, Leisure and Health Management, Tainan University of Technology, No.529, Zhongzheng Rd., Yongkang District, Tainan City, 710302, Taiwan (R.O.C.). chenkochia@gmail.com.ORCID http://orcid.org/0000-0002-5098-9561

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the dose-response relationship between various exercise modalities and their effectiveness in enhancing balance in Parkinson's disease (PD) patients.

methodsSearches were conducted in PubMed, Medline, Embase, PsycINFO, Cochrane Library, and Web of Science from inception to July 23th, 2024. Data were analyzed using R software, with the MBNMA and RJAGS packages to compute standardized mean differences (SMD) and 95% credible intervals (95% CrI). The network's risk of bias was rigorously evaluated by two independent reviewers using the ROB2 tool.

resultsThe analysis included 73 studies with 3,747 PD patients, assessing the effects of different exercises on balance. The findings demonstrate a nonlinear increasing dose-response relationship. Dance was the most effective, with an optimal dose of 1000 METs-min/week, closely followed by aerobic exercise (AE) at 1200 METs-min/week. Aquatic exercise (AQE), multicomponent exercise (MulC), and sensory exercise (SE) exhibited an inverted U-shaped response, with peak improvements at 700 METs-min/week for AQE, 610 METs-min/week for MulC, and 620 METs-min/week for SE. Balance and gait training (BGT), mind-body exercise (MBE), and resistance training (RT) also significantly improved balance, with optimal dosages below 750 METs-min/week.

conclusionSpecific exercises, particularly dance at 1000 METs-min/week, significantly enhance balance in PD patients. Nonlinear dose-response patterns and inverted U-shaped curves were evident, supporting the necessity for personalized exercise prescriptions based on the minimal clinically important difference (MCID) identified for AE, AQE, MBE, MulC, and SE, to optimize therapeutic outcomes. PROSPERO registration number: CRD42024517241.

Indexed as

Exercise TherapyParkinson DiseasePostural BalanceBayes TheoremHumansBalance test batteriesBayesian network meta-analysisDose–responseExerciseParkinson's diseaseRCTs

Identifiers

PMID40423886
PMCPMC12394369

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.