ArticleJournal of the National Cancer Institute2025
Risk of aggressive prostate cancer with successive generations in the US among Latino men.
Article in Journal of the National Cancer Institute, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
backgroundUS-born Latino men have a higher incidence of prostate cancer than foreign-born Latino men. It was not clear whether these increases were exclusively due to increased detection of prostate cancer in the United States, changes in risk factors of prostate cancer, or a combination of both.
methodsIn the Multiethnic Cohort we evaluated the association between generational status and risk of prostate cancer in 19 597 Latino men, adjusting for demographic and lifestyle factors and individual- and neighborhood-level socioeconomic status, as well as history of prostate-specific antigen screening. Additional adjustments on polygenic risk score and genetic ancestry were included in the sensitivity analysis in the biorepository cohort with genetic data.
resultsThis analysis included 10 241 first-generation, 4610 second-generation, and 4746 third-generation Latino men, among whom 2366 were diagnosed with prostate cancer during an average of 19.2 years of follow-up. After adjusting for covariates, we observed no association between generational status and risk of overall, localized, or low-grade prostate cancer. A per generation increase was statistically significantly associated with a 13%-15% elevated risk of high-grade, advanced, or aggressive prostate cancer. These associations with aggressive forms of prostate cancer remained statistically significant in the biorepository cohort with additional adjustment on polygenic risk score and genetic ancestry.
conclusionsSuccessive generations in the United States were associated with an increased risk of aggressive forms of prostate cancer among Latino men, and the observed increases cannot be explained by differences in genetic susceptibility, ancestry, prostate-specific antigen screening, lifestyle, or socioeconomic status factors. Further investigations are needed to identify additional factors that contribute to this increased risk.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.