SynthesisNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association2025
Long-term risks of adverse kidney outcomes after acute kidney injury: a systematic review and meta-analysis.
Synthesis in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed.
- Metabolic memory in the kidney: how lactate and lactylation drive the path from acute injury to chronic disease.Renal failure · 2026Review
- Macrophage-Fibroblast Crosstalk in Kidney Injury: A Narrative Review.International journal of molecular sciences · 2026Review
- Apelin-13 Pretreatment Attenuates Age-Associated Renal Fibrotic Remodeling Following I/R Injury.Biomedicines · 2026Article
- Acute Kidney Injury-to-Chronic Kidney Disease Transition-Associated Macrophage Subtypes: Biological Functions and Intercellular Crosstalk.International journal of molecular sciences · 2026Review
- Twist Family BHLH Transcription Factor 1 orchestrates hypoxia-lactate crosstalk to bridge glycolytic flux and tubular maladaptation in fibrotic kidneys.Molecular biomedicine · 2026Article
- Redox-Mediated Mitochondrial Dysfunction as a Common Pathogenic Axis in Acute Kidney Injury and Chronic Kidney Disease.Biomolecules · 2026Review
- Aortic calcification and contrast-associated acute kidney injury in patients undergoing urgent coronary angiography.Heart and vessels · 2026Article
- Renal glucose metabolic enzyme expression during AKI-to-CKD transition.International urology and nephrology · 2026Article
- Acute kidney injury: incidence and quality of care in patients with type 2 diabetes.Clinical kidney journal · 2026Article
- Article
- Outcomes of acute kidney injury in critically ill adults with tropical acute febrile illness: Prospective observational study.World journal of critical care medicine · 2026Article
- Septic Shock and Severe AKI Caused by West Nile Virus in Southern France.Kidney international reports · 2026Article
- Long-term risks of major adverse cardiovascular events after acute kidney injury: a systematic review and meta-analysis.Clinical kidney journal · 2026Article
- Mechanisms Linking Recurrent Bacterial Urinary Tract Infections to Chronic Kidney Disease Progression.International journal of molecular sciences · 2026Review
- Plasma from Cardiac Surgery Patients Induces Endothelial and Tubular Epithelial Cell Damage: Potential Role in Acute Kidney Injury Development-A Preliminary Report.International journal of molecular sciences · 2026Article
- Transition from acute kidney injury to chronic kidney disease: molecular mechanisms and therapeutic interventions.Molecular biomedicine · 2026Review
- Research progress on biomarkers for acute kidney injury in children.Pediatric nephrology (Berlin, Germany) · 2026Review
- Postoperative Septic Shock After Esophagectomy for Esophageal Cancer: Risk Factors and Impact on Short- and Long-Term Survival.Journal of personalized medicine · 2026Article
- Review
- Scoping Review of Interventions to Prevent CKD of Unknown Origin in Working Populations.Kidney international reports · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
backgroundAcute kidney injury (AKI) is associated with increased risks of incidence or progression of chronic kidney disease (CKD), kidney failure (KF), or major adverse kidney events (MAKE), however, it remains unclear which individuals have higher risks. Hence, we systematically reviewed the literature to explore differences in kidney dysfunction risks between AKI stages, AKI durations, and clinical settings.
methodsWe performed a systematic search in PubMed and Embase to identify studies that examined at least one outcome of interest in individuals with AKI versus without AKI, with a minimum follow-up of one year. Hazard/odds ratios (HR/OR) were pooled using random effects models. Heterogeneity across patient and disease characteristics was examined using subgroup and meta-regression analyses.
resultsWe searched 70 studies, encompassing 1 838 668 individuals, including 165 715 with AKI. All studies were of moderate to high quality. Individuals with AKI had higher risks of CKD incidence [AKI 25.8%/no AKI 8.7%; HR 2.36 [95% confidence interval (CI) 1.77-2.94)]], CKD progression [AKI 43.1%/no AKI 35.6%; HR 1.83 (95%CI 1.26-2.40)], KF [AKI 2.9%/no AKI 0.5%; HR 2.64 (95%CI 2.03-3.25)], and MAKE [AKI 59.0%/no AKI 32.7%; OR 2.77 (95%CI 2.01-3.53)]. The pooled effect estimates for CKD incidence after AKI lasting <3 days remained significant [OR 2.37 (95%CI 1.68-3.07)], even in individuals with AKI stage 1 only [HR 1.49 (95%CI 1.44-1.55)]. Diabetes mellitus, hypertension, requiring acute dialysis, cardiovascular surgery, or coronary artery disease were associated with higher CKD incidence or progression risks.
conclusionsRisks for kidney dysfunction were higher for all individuals with AKI. Risk estimates were heterogeneous between patient subgroups, based on AKI stage, AKI duration, and clinical setting, yet even individuals with the lowest stage or shortest duration of AKI remained at higher risk for CKD incidence or progression. This highlights the need to develop tailored follow-up strategies to recognize kidney function decline post-AKI and initiate kidney protective measures in a timely fashion.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.