Evidence map›Paper›PMID 40425149›Full record

ArticleEuropean journal of dentistry2025

Correlation between Salivary Oxidative Stress Biomarkers and Clinical Severity of Radiation-Induced Oral Mucositis in Head and Neck Cancer Patients.

Nurina Febriyanti Ayuningtyas, Fatimah Fauzi Basalamah, Gisela Lalita Brahmanikanya, Fatma Yasmin Mahdani, Adiastuti Endah Parmadiati, Desiana Radithia, Diah Savitri Ernawati, Madhu Shrestha, Ulinta Purwati Pasaribu, Satutya Wicaksono

Abstract read
In one paragraph

Article in European journal of dentistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nurina Febriyanti AyuningtyasDepartment of Oral Medicine, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
Fatimah Fauzi BasalamahOral Medicine Specialist Study Programme, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
Gisela Lalita BrahmanikanyaOral Medicine Specialist Study Programme, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
Fatma Yasmin MahdaniDepartment of Oral Medicine, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.ORCID 0000-0001-6919-418X
Adiastuti Endah ParmadiatiDepartment of Oral Medicine, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
Desiana RadithiaDepartment of Oral Medicine, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.ORCID 0000-0003-2031-6283
Diah Savitri ErnawatiDepartment of Oral Medicine, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
Madhu ShresthaDepartment of Diagnostic Sciences, College of Dentistry, Texas A&M University, Dallas, Texas, United States.
Ulinta Purwati PasaribuDepartment of Radiology, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
Satutya WicaksonoDepartment of Oral Medicine, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.ORCID 0000-0002-4982-329X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Radiation-induced oral mucositis (RIOM) is the most common side effect of radiotherapy (RT) in head and neck cancer (HNC) patients. Oxidative stress plays a major role in the multistep pathogenesis of RIOM. However, the current understanding of the relationship between salivary biomarkers of oxidative stress and the clinical severity of RIOM remains limited. This study aims to analyze the correlation between salivary oxidative stress biomarkers and the clinical severity of RIOM.This cross-sectional study analyzed the levels of salivary oxidative stress biomarkers from 25 HNC patients who underwent RT using enzyme-linked immunosorbent assay and the clinical grades of RIOM in the cohort. The data were then analyzed using the Spearman's correlation statistical test (

Identifiers

PMID40425149
PMCPMC12494423

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.