ArticleRNA (New York, N.Y.)2025
OpenASO: RNA Rescue-designing splice-modulating antisense oligonucleotides through community science.
Victor Tse, Martin Guiterrez, Jill Townley, Jonathan Romano, Jennifer Pearl, Guillermo Chacaltana, Eterna Players, Rhiju Das, Jeremy R Sanford, Michael D Stone
Abstract read
In one paragraphArticle in RNA (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
10 authors.
Victor TseDepartment of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, California 95064, USA.ORCID 0009-0001-2072-591X Martin GuiterrezDepartment of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, California 95064, USA.
Guillermo ChacaltanaCenter for Molecular Biology of RNA, University of California Santa Cruz, Santa Cruz, California 95064, USA.
Jeremy R SanfordDepartment of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, California 95064, USA mds@ucsc.edu jsanfor2@ucsc.edu.ORCID 0000-0002-1131-1627 Michael D StoneCenter for Molecular Biology of RNA, University of California Santa Cruz, Santa Cruz, California 95064, USA mds@ucsc.edu jsanfor2@ucsc.edu.ORCID 0000-0002-2060-4501 Funding
Next-generation computational/chemical methods for complex RNA structuresR35GM122579 · NIGMS · STANFORD UNIVERSITY · PI Rhiju Das · 2017 to 2026
$7.2MStructure and dynamics of the Tetrahymena telomerase ribonucleoproteinR01GM095850 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI STONE, MICHAEL D · 2011 to 2023
$4.4MRegulation of mRNA FateR35GM130361 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI Jeremy Robert Sanford · 2019 to 2026
$3.1MStructure and Dynamics of Telomeres and TelomeraseR35GM153235 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI Michael D Stone · 2024 to 2026
$1.3MNIGMS NIH HHS R01 GM095850NIGMS NIH HHS R35 GM122579NIGMS NIH HHS R35 GM130361NIGMS NIH HHS R35 GM153235
6 · The paper itselfAbstract
Splice-modulating antisense oligonucleotides (ASOs) are precision RNA-based drugs that are becoming an established modality to treat human disease. Previously, we reported the discovery of ASOs that target a novel, putative intronic RNA structure to rescue splicing of multiple pathogenic variants of
Indexed as
Hemophilia AOligonucleotides, AntisenseRNARNA SplicingCrowdsourcingExonsFactor VIIIHumansIntronsNucleic Acid ConformationFactor VIIIOligonucleotides, AntisenseRNAantisense oligonucleotidescommunity sciencedrug discoveryhemophilia ARNA splicingRNA structure
Identifiers
PMID40425312
PMCPMC12265936
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